Evidence map›Paper›PMID 34785511›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy.

Jian Gao, Xiangyun Yang, Xiongying Chen, Rui Liu, Pengchong Wang, Fanqiang Meng, Zhanjiang Li, Yuan Zhou

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Jian GaoFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Xiangyun YangFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Xiongying ChenFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Rui LiuFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Pengchong WangFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Fanqiang MengFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Zhanjiang LiFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Yuan ZhouFrom the National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li, Zhou); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (Gao, Yang, Chen, Liu, Wang, Meng, Li); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou); and the Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China (Zhou).
Beijing Anding Hospital · CNInstitute of Psychology, Chinese Academy of Sciences · CNUniversity of Chinese Academy of Sciences · CNCapital Medical University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive behavioural therapy (CBT) is considered an effective first-line treatment for obsessive-compulsive disorder (OCD). However, the neural basis of CBT for OCD has not yet been elucidated. The role of the amygdala in OCD and its functional coupling with the cerebral cortex have received increasing attention, and may provide new understanding of the neural basis of CBT for OCD.

methodsWe acquired baseline resting-state functional MRI (fMRI) scans from 45 unmedicated patients with OCD and 40 healthy controls; we then acquired another wave of resting-state fMRI scans from the patients with OCD after 12 weeks of CBT. We performed seed-based resting-state functional connectivity analyses of the amygdala subregions to examine changes in patients with OCD as a result of CBT.

resultsCompared to healthy controls, patients with OCD showed significantly increased resting-state functional connectivity at baseline between the left basolateral amygdala and the right middle frontal gyrus, and between the superficial amygdala and the right cuneus. In patients with OCD who responded to CBT, we found decreased resting-state functional connectivity after CBT between the amygdala subregions and the visual association cortices and increased resting-state functional connectivity between the amygdala subregions and the right inferior parietal lobe. Furthermore, these changes in resting-state functional connectivity were positively associated with changes in scores on the compulsion or obsession subscales of the Yale-Brown Obsessive-Compulsive Scale. LIMITATIONS: Because of the lack of a second scan for healthy controls after 12 weeks, our results may have been confounded by other variables.

conclusionOur findings yield insights into the pathophysiology of OCD; they also reveal the potential neural changes elicited by CBT, and thus have implications for guiding effective treatment strategies with CBT for OCD.

Indexed as

Cognitive Behavioral TherapyObsessive-Compulsive DisorderAmygdalaBrain MappingHumansMagnetic Resonance ImagingNeural Pathways

Identifiers

PMID34785511
PMCPMC8598242
OpenAlexW3213706563

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.