Evidence map›Paper›PMID 34785406›Full record

ArticleNeurobiology of aging2022

Paradoxical cognitive trajectories in men from earlier to later adulthood.

Graham M L Eglit, Jeremy A Elman, Mathew S Panizzon, Mark Sanderson-Cimino, McKenna E Williams, Anders M Dale, Lisa T Eyler, Christine Fennema-Notestine, Nathan A Gillespie, Daniel E Gustavson and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Graham M L EglitVeterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA. Electronic address: geglit@health.ucsd.edu.
Jeremy A ElmanDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Mathew S PanizzonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Mark Sanderson-CiminoDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; San Diego State University/University of California, San Diego Joint Doctoral Program, San Diego, CA, USA.
McKenna E WilliamsDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; San Diego State University/University of California, San Diego Joint Doctoral Program, San Diego, CA, USA.
Anders M DaleDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Department of Radiology, University of California, San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Lisa T EylerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Daniel E GustavsonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Sean N HattonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
Donald J HaglerDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Richard L HaugerCenter for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Amy J JakVeterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Mark W LogueNational Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, USA; Psychiatry and Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Linda K McEvoyDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Ruth E McKenzieDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA; School of Education and Social Policy, Merrimack College, North Andover, MA, USA.
Michael C NealeVirginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Olivia PuckettDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Chandra A ReynoldsDepartment of Psychology, University of California Riverside, Riverside, CA, USA.
Rosemary ToomeyDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Xin M TuDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Nathan WhitselDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Hong XianDepartment of Epidemiology and Biostatistics, St. Louis University, St. Louis, MO, USA.
Michael J LyonsVeterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Carol E FranzVeterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
Genetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8M
Clarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6M
Effects of Androgen Deprivation Therapy on Preclinical Symptoms of Alzheimer's DiseaseR01AG056410 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANIZZON, MATTHEW S · 2017 to 2021
$3.3M
SES health gradients in late life: testing models of gene-environment interplay in an international twin consortiumR01AG059329 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, BRIAN K., GATZ, MARGARET · 2018 to 2022
$2.9M
The VETSA Longitudinal Twin Study of Cortisol and AgingR01AG022982 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2004 to 2007
$2.6M
Moderate alcohol use: risk or protective factor for age-related cognitive decline, mild cognitive impairment, and brain health in agingR01AG062483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCEVOY, LINDA KATHLEEN · 2019 to 2021
$1.6M
Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneityK01AG063805 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A · 2021 to 2024
$516k
Practice Effects in Cognitive Aging: Implications for Biomarkers and Early DiagnosisF31AG064834 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDERSON-CIMINO, MARK · 2020 to 2021
$78k
CSRD VA I01 CX001727NCATS NIH HHS KL2 TR001444NIA NIH HHS F31 AG064834NIA NIH HHS K01 AG063805NIA NIH HHS P01 AG055367NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG056410NIA NIH HHS R01 AG059329NIA NIH HHS R01 AG060470NIA NIH HHS R01 AG062483NIA NIH HHS R01 AG064955
6 · The paper itself

Abstract

Because longitudinal studies of aging typically lack cognitive data from earlier ages, it is unclear how general cognitive ability (GCA) changes throughout the life course. In 1173 Vietnam Era Twin Study of Aging (VETSA) participants, we assessed young adult GCA at average age 20 and current GCA at 3 VETSA assessments beginning at average age 56. The same GCA index was used throughout. Higher young adult GCA and better GCA maintenance were associated with stronger specific cognitive abilities from age 51 to 73. Given equivalent GCA at age 56, individuals who had higher age 20 GCA outperformed those whose GCA remained stable in terms of memory, executive function, and working memory abilities from age 51 to 73. Thus, paradoxically, despite poorer maintenance of GCA, high young adult GCA still conferred benefits. Advanced predicted brain age and the combination of elevated vascular burden and APOE-ε4 status were associated with poorer maintenance of GCA. These findings highlight the importance of distinguishing between peak and current GCA for greater understanding of cognitive aging.

Indexed as

CognitionExecutive FunctionAdultAgedAgingApolipoproteins EBrainHumansLongitudinal StudiesMaleMemoryMemory, Short-TermMiddle AgedNeuropsychological TestsTwinsTwin Studies as TopicApolipoproteins ECognitive agingDementiaGeneral cognitive abilityLongitudinal studiesNeuropsychology

Identifiers

PMID34785406
PMCPMC8715388

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.