ArticleGenome biology2021
Resequencing of 388 cassava accessions identifies valuable loci and selection for variation in heterozygosity.
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 44 citations in OpenAlex.
- Comparison of Heterozygosity and Genetic Diversity Between Wild and Domesticated Macadamia.Biology · 2026Article
- From structural pangenomes to functional panomics in plants.Molecular biology and evolution · 2026Review
- Exploring genetic diversity and selective signatures, a journey through Colombian cassava's landscape.Journal of plant research · 2026Article
- Article
- Transcriptome-Based Identification of Reference Genes for Expression Analysis in Cassava UnderPlants (Basel, Switzerland) · 2025Article
- Genomic-Wide Association Markers and Candidate Genes for the High-Protein Trait in Storage Roots of Cassava (Plants (Basel, Switzerland) · 2025Article
- The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree.Nature communications · 2025Article
- Comprehensive analysis of 385 chloroplast genomes unveils phylogenetic relationships and evolutionary history in cassava.BMC plant biology · 2025Article
- TropiCODB: A multi-omics resource for supporting biodesign in tropical crops.Biodesign research · 2025Article
- Advancements and strategies of genetic improvement in cassava (Horticulture research · 2025Article
- GenoBaits Cassava35K: high-resolution multi-SNP arrays for genetic analysis and molecular breeding using targeted sequencing and liquid chip technology.Horticulture research · 2025Article
- KIN10-mediated HB16 protein phosphorylation and self-association improve cassava disease resistance by transcriptional activation of lignin biosynthesis genes.Plant biotechnology journal · 2024Article
- TCOD: an integrated resource for tropical crops.Nucleic acids research · 2024Article
- Metabolic GWAS-based dissection of genetic basis underlying nutrient quality variation and domestication of cassava storage root.Genome biology · 2023Article
- Genomic insights into selection for heterozygous alleles and woody traits in Populus tomentosa.Plant biotechnology journal · 2023Article
- Article
- Analysis of the molecular and biochemical mechanisms involved in the symbiotic relationship betweenFrontiers in plant science · 2023Article
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Authors and funding
34 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeterozygous genomes are widespread in outcrossing and clonally propagated crops. However, the variation in heterozygosity underlying key agronomic traits and crop domestication remains largely unknown. Cassava is a staple crop in Africa and other tropical regions and has a highly heterozygous genome.
resultsWe describe a genomic variation map from 388 resequenced genomes of cassava cultivars and wild accessions. We identify 52 loci for 23 agronomic traits through a genome-wide association study. Eighteen allelic variations in heterozygosity for nine candidate genes are significantly associated with seven key agronomic traits. We detect 81 selective sweeps with decreasing heterozygosity and nucleotide diversity, harboring 548 genes, which are enriched in multiple biological processes including growth, development, hormone metabolisms and responses, and immune-related processes. Artificial selection for decreased heterozygosity has contributed to the domestication of the large starchy storage root of cassava. Selection for homozygous GG allele in MeTIR1 during domestication contributes to increased starch content. Selection of homozygous AA allele in MeAHL17 is associated with increased storage root weight and cassava bacterial blight (CBB) susceptibility. We have verified the positive roles of MeTIR1 in increasing starch content and MeAHL17 in resistance to CBB by transient overexpression and silencing analysis. The allelic combinations in MeTIR1 and MeAHL17 may result in high starch content and resistance to CBB.
conclusionsThis study provides insights into allelic variation in heterozygosity associated with key agronomic traits and cassava domestication. It also offers valuable resources for the improvement of cassava and other highly heterozygous crops.
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