Evidence map›Paper›PMID 34784734›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Multiple Social Vulnerabilities to Health Disparities and Hypertension and Death in the REGARDS Study.

Jordan B King, Laura C Pinheiro, Joanna Bryan Ringel, Adam P Bress, Daichi Shimbo, Paul Muntner, Kristi Reynolds, Mary Cushman, George Howard, Jennifer J Manly and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Area deprivation, social vulnerability, and post-pregnancy blood pressure.medRxiv : the preprint server for health sciences · 2026
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  19. Social determinants of health and cancer screening in China.The Lancet regional health. Western Pacific · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Jordan B KingDepartment of Population Health Sciences, School of Medicine, University of Utah (J.B.K., A.P.B.).ORCID 0000-0002-6783-7951
Laura C PinheiroDepartment of Medicine, Weill Medical College of Cornell University (L.C.P., J.B.R., M.M.S.).ORCID 0000-0002-6920-8526
Joanna Bryan RingelDepartment of Medicine, Weill Medical College of Cornell University (L.C.P., J.B.R., M.M.S.).
Adam P BressDepartment of Population Health Sciences, School of Medicine, University of Utah (J.B.K., A.P.B.).ORCID 0000-0002-2259-5039
Daichi ShimboDepartment of Medicine (D.S.), Columbia University Vagelos College of Physicians and Surgeons.ORCID 0000-0001-6302-8834
Paul MuntnerDepartment of Epidemiology (P.M.), School of Public Health, University of Alabama at Birmingham.ORCID 0000-0002-4711-5492
Kristi ReynoldsDepartment of Research and Evaluation, Kaiser Permanente Southern California (K.R.).ORCID 0000-0001-7619-1649
Mary CushmanDepartment of Medicine, Larner College of Medicine, University of Vermont (M.C.).ORCID 0000-0002-7871-6143
George HowardDepartment of Biostatistics (G.H.), School of Public Health, University of Alabama at Birmingham.ORCID 0000-0002-3068-5720
Jennifer J ManlyDepartment of Neurology (J.J.M.), Columbia University Vagelos College of Physicians and Surgeons.ORCID 0000-0002-9481-7497
Monika M SaffordDepartment of Medicine, Weill Medical College of Cornell University (L.C.P., J.B.R., M.M.S.).ORCID 0000-0002-3060-0563
Cornell University · USColumbia College · CAKaiser Permanente · USAlabama Department of Public Health · USUniversity of Alabama at Birmingham · USUniversity of Utah · USUniversity of Vermont · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI W Timothy GARVEY · 2013 to 2026
$19.5M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-4 (REGARDS-MI-4)R01HL165452 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2022 to 2025
$8.3M
Genetic ancestry and antihypertensive medication responses in African AmericansK01HL133468 · NHLBI · UNIVERSITY OF UTAH · PI BRESS, ADAM P · 2016 to 2020
$787k
NHLBI NIH HHS K01 HL133468NHLBI NIH HHS R01 HL080477NHLBI NIH HHS R01 HL165452NIDDK NIH HHS P30 DK079626NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Social vulnerabilities increase the risk of developing hypertension and lower life expectancy, but the effect of an individual's overall vulnerability burden is unknown. Our objective was to determine the association of social vulnerability count and the risk of developing hypertension or dying over 10 years and whether these associations vary by race. We used the REGARDS study (Reasons for Geographic and Racial Differences in Stroke) and included participants without baseline hypertension. The primary exposure was the count of social vulnerabilities defined across economic, education, health and health care, neighborhood and built environment, and social and community context domains. Among 5425 participants of mean age 64±10 SD years of which 24% were Black participants, 1468 (31%) had 1 vulnerability and 717 (15%) had ≥2 vulnerabilities. Compared with participants without vulnerabilities, the adjusted relative risk ratio for developing hypertension was 1.16 (95% CI, 0.99-1.36) and 1.49 (95% CI, 1.20-1.85) for individuals with 1 and ≥2 vulnerabilities, respectively. The adjusted relative risk ratio for death was 1.55 (95% CI, 1.24-1.93) and 2.30 (95% CI, 1.75-3.04) for individuals with 1 and ≥2 vulnerabilities, respectively. A greater proportion of Black participants developed hypertension and died than did White participants (hypertension, 38% versus 31%; death, 25% versus 20%). The vulnerability count association was strongest in White participants (

Indexed as

Social Determinants of HealthSocial VulnerabilityAgedBlood PressureFemaleHealth Status DisparitiesHumansHypertensionMaleMiddle AgedRisk FactorsSex FactorsSurvival Ratecardiovascular diseaseshypertensionmortalitypublic healthstroke

Identifiers

PMID34784734
PMCPMC8665033
OpenAlexW3211621676

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.