Evidence map›Paper›PMID 34784477›Full record

ArticleBioconjugate chemistry2021

Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations.

Daniel Willén, Roberto Mastio, Zackarias Söderlund, Sophie Manner, Gunilla Westergren-Thorsson, Emil Tykesson, Ulf Ellervik

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel WillénCentre for Analysis and Synthesis, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
Roberto MastioCentre for Analysis and Synthesis, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
Zackarias SöderlundDepartment of Experimental Medical Science, Lund University, P.O. Box 117, SE-221 00 Lund, Sweden.
Sophie MannerCentre for Analysis and Synthesis, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
Gunilla Westergren-ThorssonDepartment of Experimental Medical Science, Lund University, P.O. Box 117, SE-221 00 Lund, Sweden.
Emil TykessonDepartment of Experimental Medical Science, Lund University, P.O. Box 117, SE-221 00 Lund, Sweden.
Ulf EllervikCentre for Analysis and Synthesis, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.ORCID 0000-0001-5287-0137
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosaminoglycan (GAG) chains with physiologically relevant lengths and sulfation patterns. Finally, we demonstrate its usefulness by conjugation to the Alexa Fluor 647 and TAMRA fluorophores and coupling to a surface plasmon resonance chip for interaction studies with the hepatocyte growth factor known to interact with the GAG heparan sulfate.

Indexed as

AzidesClick ChemistryGalactosyltransferasesGlycosaminoglycansAnimalsGlycosidesHeparan SulfateHumansSurface Plasmon ResonanceAzidesGalactosyltransferasesGlycosaminoglycansGlycosidesHeparan Sulfatexylosidesxylosylprotein 4-beta-galactosyltransferase

Identifiers

PMID34784477
PMCPMC8678990
OpenAlexW3212612307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.