Evidence map›Paper›PMID 34784433›Full record

ArticleChembiochem : a European journal of chemical biology2022

Self-Assembly of Unprotected Dipeptides into Hydrogels: Water-Channels Make the Difference.

Ottavia Bellotto, Slavko Kralj, Michele Melchionna, Paolo Pengo, Matic Kisovec, Marjetka Podobnik, Rita De Zorzi, Silvia Marchesan

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Supramolecular Behaviour of Heterochiral Dipeptides With Ile.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. 2D Interfacial Crystallization Stabilized by Short-Chain Aliphatic Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  6. Self-Assembled Peptide Nanostructures for ECM Biomimicry.Nanomaterials (Basel, Switzerland) · 2022
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ottavia BellottoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.
Slavko KraljMaterials Synthesis Department, Jožef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.
Michele MelchionnaDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.
Paolo PengoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.
Matic KisovecDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.
Marjetka PodobnikDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.
Rita De ZorziDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.
Silvia MarchesanDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.ORCID 0000-0001-6089-3873

Funding

CENN Nanocenter (Slovenia)National Institute of Chemistry (Slovenia) P1-0391Slovenian Research Agency J2-3040Slovenian Research Agency J2-3043Slovenian Research Agency J2-3046Slovenian Research Agency P2-0089University of Trieste
6 · The paper itself

Abstract

Unprotected dipeptides are attractive building blocks for environmentally friendly hydrogel biomaterials by virtue of their low-cost and ease of preparation. This work investigates the self-assembling behaviour of the distinct stereoisomers of Ile-Phe and Phe-Ile in phosphate buffered saline (PBS) to form hydrogels, using transmission electron microscopy (TEM), attenuated total reflectance infrared spectroscopy (ATR-IR), circular dichroism (CD), and oscillatory rheometry. Each peptide purity and identity was also confirmed by

Indexed as

DipeptidesHydrogelsStereoisomerismWaterDipeptidesHydrogelsWaterchiralityD-amino acidshydrogelspeptidesself-assembly

Identifiers

PMID34784433
PMCPMC9299199

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.