Evidence map›Paper›PMID 34784046›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Assessment of Serum Bactericidal and Opsonophagocytic Activity of Antibodies to Gonococcal Vaccine Targets.

Evgeny A Semchenko, Freda E-C Jen, Michael P Jennings, Kate L Seib

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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  6. Clinical microbiology reviews · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Evgeny A SemchenkoInstitute for Glycomics, Griffith University, Gold Coast, QLD, Australia. e.semchenko@griffith.edu.au.
Freda E-C JenInstitute for Glycomics, Griffith University, Gold Coast, QLD, Australia.
Michael P JenningsInstitute for Glycomics, Griffith University, Gold Coast, QLD, Australia.
Kate L SeibInstitute for Glycomics, Griffith University, Gold Coast, QLD, Australia. k.seib@griffith.edu.au.
Griffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is no vaccine available to prevent Neisseria gonorrhoeae infection, however there is currently a high level of interest in developing gonococcal vaccines due to the increasing number of cases and continuing emergence of antimicrobial resistance worldwide. A key aspect of vaccine development is the investigation of the functional immune response raised to the vaccine targets under investigation. Here, we describe two assays used to assess the functional immune response raised against gonococcal vaccine targets: the serum bactericidal assay (SBA) and the opsonophagocytic assay (OPA).

Indexed as

GonorrheaAntibodies, BacterialBacterial VaccinesBlood Bactericidal ActivityHumansNeisseria gonorrhoeaeAntibodies, BacterialBacterial VaccinesAntibodyAntigenComplementImmune responseNeutrophilN. gonorrhoeaeOpsonophagocytic assay (OPA)Polymorphonuclear leukocyte (PMN)Serum bactericidal assay (SBA )Vaccine

Identifiers

PMID34784046
OpenAlexW3211788399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.