Evidence map›Paper›PMID 34784036›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery.

Lili Zhao, Sahra Bashiri, Istvan Toth, Mariusz Skwarczynski

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lili ZhaoSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Sahra BashiriSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Istvan TothSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Mariusz SkwarczynskiSchool of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia. m.skwarczynski@uq.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of delivery vehicles have been explored as adjuvanting/delivery platforms for peptide-based subunit vaccines. Polysaccharide-based systems have been found to be especially attractive due to their immune stimulating properties, biodegradability, biocompatibility, and low toxicity. Among them, chitosan and its derivatives are the most common cationic nanocarriers used for the delivery of antigens. Trimethyl chitosan (TMC) is a partially quaternized, water-soluble, and mucoadhesive derivative of chitosan. This chapter describes the preparation of a TMC-based polyelectrolyte complex as a delivery system for peptide subunit vaccines.

Indexed as

PolyelectrolytesChitosanDrug CarriersNanoparticlesPeptidesVaccines, SubunitChitosanDrug CarriersPeptidesPolyelectrolytesVaccines, SubunitAlginateNanoparticlesPeptide subunit vaccinePolyelectrolyte complexesTrimethyl chitosan

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.