Evidence map›Paper›PMID 34783980›Full record

ArticleInternational urology and nephrology2022

The protective effect of manganese superoxide dismutase from thermophilic bacterium HB27 on hydrochloric acid-induced chemical cystitis in rats.

Nai-Wen Chen, Jin-Lai Gao, Hai-Long Li, Hong Xu, Ling-Feng Wu, Fan-Guo Meng, Wei Chen, Yi-Fang Cao, Wen-Hua Xie, Xiao-Qin Zhang and 4 more

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In one paragraph

Article in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Nai-Wen Chen *Department of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China.
Jin-Lai Gao *Department of Pharmacology, College of Medical, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China.
Hai-Long LiRedox Medical Center for Public Health, Medical College of Soochow University, Suzhou, 215123, Jiangsu, China.
Hong XuDepartment of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China.
Ling-Feng WuDepartment of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China.
Fan-Guo MengRedox Medical Center for Public Health, Medical College of Soochow University, Suzhou, 215123, Jiangsu, China.
Wei ChenDepartment of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China.
Yi-Fang CaoDepartment of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China.
Wen-Hua XieDepartment of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China.
Xiao-Qin ZhangDepartment of Pharmacy, College of Medical, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China.
Shi-Hui LiuDepartment of Pharmacy, College of Medical, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China.
Jing JinDepartment of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China. jinjing@zjxu.edu.cn.
Yi HeDepartment of Urology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, China. heyi@zjxu.edu.cn.
Jian-Wei LvDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, People's Republic of China. ljwass@126.com.
Jiaxing University · CNFirst Hospital of Jiaxing · CNSoochow University · CNRenji Hospital · CN

Funding

Jiaxing Key Laboratory of Precise Diagnosis and Treatment of Urological Tumor 2020-mnzdsysJiaxing Medical Key Subject Funding of Zhejiang Province 2019-zc-07Medical Scientific Research Foundation of Zhejiang Province 2021RC129Research Foundation of the Affiliated Hospital of Jiaxing University 2021-YA-013Research Fund of clinical medicine discipline construction from Jiaxing University 71018006
6 · The paper itself

Abstract

purposeTo evaluate the effects of manganese superoxide dismutase (Mn-SOD) from thermophilic bacterium HB27 (name as Tt-SOD) on chemical cystitis.

methodsControl and experimental rats were infused by intravesical saline or hydrochloric acid (HCl) on the first day of the experiments. Saline, sodium hyaluronate (SH) or Tt-SOD were infused intravesically once a day for three consequent days. On the fifth day, the rats were weighted and sacrificed following a pain threshold test. The bladder was harvested for histological and biochemical analyses.

resultsTt-SOD could reduce the bladder index, infiltration of inflammatory cells in tissues, serum inflammatory factors and SOD levels, mRNA expression of inflammatory factors in tissues, and increase perineal mechanical pain threshold and serum MDA and ROS levels in HCl-induced chemical cystitis. Furthermore, Tt-SOD alleviated inflammation and oxidative stress by the negative regulation of the NF-κB p65 and p38 MAPK signaling pathway.

conclusionsIntravesical instillation of Tt-SOD provides protective effects against HCl-induced cystitis.

Indexed as

Bacterial ProteinsCystitisSuperoxide DismutaseAnimalsHydrochloric AcidInflammationRatsRats, Sprague-DawleyUrinary BladderBacterial ProteinsHydrochloric AcidSuperoxide DismutaseBladder painCystitisSuperoxide dismutaseThermophilic bacterium

Identifiers

PMID34783980
PMCPMC9184365
OpenAlexW3212005458

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.