Evidence map›Paper›PMID 34783902›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2022

Synaptic plasticity mechanisms behind TMS efficacy: insights from its application to animal models.

Mattia Ferro, Jacopo Lamanna, Sara Spadini, Alessio Nespoli, Simone Sulpizio, Antonio Malgaroli

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mattia Ferro *Department of Psychology, Sigmund Freud University, Milan, Italy. m.ferro@milano-sfu.it.
Jacopo LamannaFaculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy. lamanna.jacopo@hsr.it.
Sara Spadini *Center for Behavioral Neuroscience and Communication (BNC), Vita-Salute San Raffaele University, Via Olgettina 58, 20132, Milan, Italy.
Alessio NespoliDepartment of Psychology, Sigmund Freud University, Milan, Italy.
Simone SulpizioDepartment of Psychology, University of Milano-Bicocca, Milan, Italy.
Antonio MalgaroliFaculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy. malgaroli.antonio@unisr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural plasticity is defined as a reshape of communication paths among neurons, expressed through changes in the number and weights of synaptic contacts. During this process, which occurs massively during early brain development but continues also in adulthood, specific brain functions are modified by activity-dependent processes, triggered by external as well as internal stimuli. Since transcranial magnetic stimulation (TMS) produces a non-invasive form of brain cells activation, many different TMS protocols have been developed to treat neurological and psychiatric conditions and proved to be beneficial. Although neural plasticity induction by TMS has been widely assessed on human subjects, we still lack compelling evidence about the actual biological and molecular mechanisms. To support a better comprehension of the involved phenomena, the main focus of this review is to summarize what has been found through the application of TMS to animal models. The hope is that such integrated view will shed light on why and how TMS so effectively works on human subjects, thus supporting a more efficient development of new protocols in the future.

Indexed as

Neuronal PlasticityTranscranial Magnetic StimulationAnimalsBrainModels, AnimalNeuronsAnimal modelBrain plasticityMental disordersSynaptic plasticityTMSTranscranial magnetic stimulation

Identifiers

PMID34783902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.