ArticleInternational orthopaedics2022
Candida periprosthetic joint infections - risk factors and outcome between albicans and non-albicans strains.
Article in International orthopaedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The heavy burden and treatment challenges of fungal periprosthetic joint infection: a systematic review of 489 joints.BMC musculoskeletal disorders · 2024Pooled it
- Fungal Periprosthetic Joint Infection: A Systematic Review and Meta-analysis of Treatment Approaches and Clinical Outcomes.Open forum infectious diseases · 2026Review
- A One- or Two-Stage Revision of Fungal Prosthetic Joint Infection: A Review of Current Knowledge, Pitfalls and Recommendations.Antibiotics (Basel, Switzerland) · 2025Review
- Outcome Predictors ofOpen forum infectious diseases · 2025Article
- Prosthetic Joint Infections due to Candida Species: A Multicenter International Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Observational
- Assessing the TNM Classification for Periprosthetic Joint Infections of the Knee: Predictive Validity for Functional and Subjective Outcomes.Journal of personalized medicine · 2025Article
- A Narrative Review of Fungal Periprosthetic Joint Infections of the Hip and Knee: Risk Factors, Microbiological Profiles, and Treatment Challenges.Journal of clinical medicine · 2025Review
- Gram negative periprosthetic hip infection: nearly 25% same pathogen infection persistence at a mean of 2 years.Archives of orthopaedic and trauma surgery · 2024Article
- The fate of fungal periprosthetic joint infection after total knee arthroplasty.International orthopaedics · 2023Article
- Is a preoperative pathogen detection a prerequisite before undergoing one-stage exchange for prosthetic joint infection of the hip?Archives of orthopaedic and trauma surgery · 2023Article
- Periprosthetic Joint Infections Caused byJournal of fungi (Basel, Switzerland) · 2022Review
- Serum and Synovial Markers in Patients with Rheumatoid Arthritis and Periprosthetic Joint Infection.Journal of personalized medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite its scarcity, fungal periprosthetic joint infection (PJI) is of great clinical relevance as diagnosis and treatment are highly challenging. Previous analyses focused on the treatment rather than the role of the causative fungal agent on clinical outcome. This is the largest study of its kind to evaluate Candida strain-dependent differences in patients with fungal PJI.
methodsWe retrospectively analyzed 29 patients who underwent surgical intervention due to Candida hip or knee PJI in our department from 2010 to 2018. PJI was defined according to IDSA, recurrent PJI according to modified Delphi consensus criteria. Statistical analysis was performed using t-test, chi-square test with Yates correction, and log rank test.
resultsBesides age and affected joint, no significant differences were found between Candida albicans and non-albicans PJI patients (75.83 versus 64.11 years, p = 0.012; 12 hip versus two knee cases, p = 0.013). Most patients received two- (27.59%) or three-stage exchange surgery (41.38%). There was a statistical trend towards an increase in surgery needed in non-albicans Candida PJI (2.92 versus 2.12; p = 0.103). After initial Candida PJI treatment, functional prosthesis implantation was achieved in 72.41% of all patients. At last follow-up, infection-free survival was at 26.79% in Candida albicans versus 72.00% in non-albicans PJI (p = 0.046).
conclusionsIn this study, we found infection-free survival rates to be significantly decreased in patients with albicans compared to non-albicans Candida PJI. While age and affected joint might play a confounding role, we speculate the causative pathogen to play a decisive role in disease progression.
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