Evidence map›Paper›PMID 34783868›Full record

ArticleUrolithiasis2022

MicroRNA-204 attenuates oxidative stress damage of renal tubular epithelial cells in calcium oxalate kidney-stone formation via MUC4-mediated ERK signaling pathway.

Zhijuan Xie, Jianying Chen, Zhong Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Urolithiasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Noncoding RNA, friend or foe for nephrolithiasis?Frontiers in cell and developmental biology · 2024
    Review
  14. Article
  15. Modulation of miR-204 Expression during Chondrogenesis.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhijuan XieThe First Affiliated Hospital, Department of Nephrology, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China.
Jianying ChenDepartment of Rheumatology and Immunology, Hunan Province Mawangdui Hospital, Changsha, 410016, People's Republic of China.
Zhong ChenThe First Affiliated Hospital, Department of Nuclear Medicine, Hengyang Medical School, University of South China, No. 69, Chuanshan Road, Hengyang, 421001, Hunan Province, People's Republic of China. 2018012403@usc.edu.cn.
University of South China · CNHunan Mawangdui Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxalate-induced oxidative stress causes damage to cells, accompanied with renal deposition of calcium oxalate crystals. Recent studies have highlighted the extensive functions of microRNAs (miRNAs) in various processes, including cellular responses to oxidative stress. Hence, this study was intended to analyze the role of miR-204 in the calcium oxalate kidney-stone formation and the underlying mechanism. In silico analysis was performed to determine the miRNA/mRNA interaction involved in calculus, while dual-luciferase reporter assay was conducted for validation. A calcium oxalate kidney-stone model was established by H

Indexed as

Calcium OxalateMicroRNAsEpithelial CellsHumansHydrogen PeroxideKidneyMAP Kinase Signaling SystemOxidative StressSignal TransductionCalcium OxalateHydrogen PeroxideMicroRNAsCalcium oxalate kidney-stone formationERK signaling pathwayMicroRNA-204MUC4Oxidative stress

Identifiers

PMID34783868
OpenAlexW3214526194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.