Evidence map›Paper›PMID 34783861›Full record

ArticleInternational urogynecology journal2022

Pelvic floor muscle injury during a difficult labor. Can tissue fatigue damage play a role?

Maria C P Vila Pouca, Marco P L Parente, Renato M Natal Jorge, John O L DeLancey, James A Ashton-Miller

Open access · greenAbstract read
In one paragraph

Article in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Maria C P Vila PoucaFaculty of Engineering of University of Porto, Porto, Portugal. maria.vp@fe.up.pt.ORCID http://orcid.org/0000-0003-3279-5285
Marco P L ParenteFaculty of Engineering of University of Porto, Porto, Portugal.
Renato M Natal JorgeFaculty of Engineering of University of Porto, Porto, Portugal.
John O L DeLanceyDepartment of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA.
James A Ashton-MillerDepartments of Mechanical and Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA.
Universidade do Porto · PTUniversity of Michigan · US

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Development of 21st Century Concepts and Tools for Quantifying Urethral Failure Mechanisms that Cause Urinary IncontinenceRC2DK122379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHTON-MILLER, JAMES ANTHONY, DELANCEY, JOHN O.L. · 2019 to 2024
$5.7M
New Perspectives on ACL InjuryR01AR054821 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHTON-MILLER, JAMES ANTHONY, WOJTYS, EDWARD M · 2007 to 2021
$3.1M
A Phase 2 clinical study of the Materna device to shorten delivery time during childbirthR44HD096987 · NICHD · MATERNA MEDICAL · PI ASHFIELD, KELLY · 2018 to 2020
$2.2M
NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR054821NIA NIH HHS P30 AG024824NICHD NIH HHS R44 HD096987NIDDK NIH HHS RC2 DK122379
6 · The paper itself

Abstract

Pubovisceral muscle (PVM) injury during a difficult vaginal delivery leads to pelvic organ prolapse later in life. If one could address how and why the muscle injury originates, one might be able to better prevent these injuries in the future. In a recent review we concluded that many atraumatic injuries of the muscle-tendon unit are consistent with it being weakened by an accumulation of passive tissue damage during repetitive loading. While the PVM can tear due to a single overstretch at the end of the second stage of labor we hypothesize that it can also be weakened by an accumulation of microdamage and then tear after a series of submaximal loading cycles. We conclude that there is strong indirect evidence that low cycle fatigue of PVM passive tissue is a possible mechanism of its proximal failure. This has implications for finding new ways to better prevent PVM injury in the future.

Indexed as

DystociaPelvic Organ ProlapseDelivery, ObstetricFemaleHumansMuscle FatiguePelvic FloorPregnancyDifficult vaginal deliveryMaterial fatiguePelvic muscle injuryRepetitive pushing

Identifiers

PMID34783861
PMCPMC8959084
OpenAlexW3211459499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.