Evidence map›Paper›PMID 34783657›Full record

ArticleeLife2021

Differential adhesion regulates neurite placement via a retrograde zippering mechanism.

Titas Sengupta, Noelle L Koonce, Nabor Vázquez-Martínez, Mark W Moyle, Leighton H Duncan, Sarah E Emerson, Xiaofei Han, Lin Shao, Yicong Wu, Anthony Santella and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Titas SenguptaDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0002-7228-719X
Noelle L KoonceDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Nabor Vázquez-MartínezDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Mark W MoyleDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Leighton H DuncanDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Sarah E EmersonDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Xiaofei HanLaboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, United States.
Lin ShaoDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Yicong WuLaboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, United States.
Anthony SantellaDevelopmental Biology Program, Sloan Kettering Institute, New Haven, United States.
Li FanDevelopmental Biology Program, Sloan Kettering Institute, New Haven, United States.
Zhirong BaoDevelopmental Biology Program, Sloan Kettering Institute, New Haven, United States.ORCID 0000-0002-2201-2745
William A MohlerDepartment of Genetics and Genome Sciences and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, United States.
Hari ShroffLaboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, United States.
Daniel A Colón-RamosDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0003-0223-7717
Yale University · USKettering University · USNational Institutes of Health · USMarine Biological Laboratory · USUConn Health · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
WormGUIDES: A Resource for Global Understanding in Dynamic Embryonic SystemsR24OD016474 · OD · YALE UNIVERSITY · PI BAO, ZHIRONG, COLON-RAMOS, DANIEL A · 2013 to 2020
$6.5M
Powering the Brain: the Cell Biology of NeuroenergeticsDP1NS111778 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2018 to 2022
$5.9M
Cellular and molecular mechanisms that temporally and spatially restrict synapticR01NS076558 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2012 to 2022
$4.1M
Molecular and cellular mechanisms required for fascicle organization during neurodevelopmentF32NS098616 · NINDS · YALE UNIVERSITY · PI MOYLE, MARK WAYNE · 2016 to 2018
$192k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA008748NIH HHS P40 OD010440NIH HHS R24 OD016474NINDS NIH HHS DP1 NS111778NINDS NIH HHS F32 NS098616NINDS NIH HHS R01 NS076558
6 · The paper itself

Abstract

During development, neurites and synapses segregate into specific neighborhoods or layers within nerve bundles. The developmental programs guiding placement of neurites in specific layers, and hence their incorporation into specific circuits, are not well understood. We implement novel imaging methods and quantitative models to document the embryonic development of the

Indexed as

AnimalsBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsCell AdhesionGene Expression RegulationNeuritesNeuronsSynapsesCaenorhabditis elegans ProteinsC. elegansdevelopmental biologydifferential adhesionIgCAMneurite placementneuroscience

Identifiers

PMID34783657
PMCPMC8843091
OpenAlexW3211786357

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.