ArticleeLife2021
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Masks and respirators for prevention of respiratory infections: a state of the science review.Clinical microbiology reviews · 2024Pooled it
- Modelling the potential use of pre-exposure prophylaxis to reduce nosocomial SARS-CoV-2 transmission.PLoS computational biology · 2025Article
- Impact of interventions to reduce nosocomial transmission of SARS-CoV-2 in English NHS Trusts: a computational modelling study.BMC infectious diseases · 2024Article
- Cytosponge procedures produce fewer respiratory aerosols and droplets than esophagogastroduodenoscopies.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024Article
- The effectiveness and efficiency of asymptomatic SARS-CoV-2 testing strategies for patient and healthcare workers within acute NHS hospitals during an omicron-like period.BMC infectious diseases · 2024Article
- COVID-19 in Workplace Settings: Lessons Learned for Occupational Medicine in the UK.La Medicina del lavoro · 2023Article
- Article
- Article
- COVID-19 lockdown revisionism.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- SARS-CoV-2 epidemiology, antibody dynamics, and neutralisation capacity in Irish healthcare workers in the era of booster COVID-19 vaccinations.Frontiers in medicine · 2023Article
- Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1-3 of the pandemic in Ireland.Epidemiology and infection · 2022Article
- Observational
- Article
- Phylodynamic analysis of SARS-CoV-2 spread in Rio de Janeiro, Brazil, highlights how metropolitan areas act as dispersal hubs for new variants.Microbial genomics · 2022Article
- Burden of SARS-CoV-2 infection in healthcare workers during second wave in England and impact of vaccines: prospective multicentre cohort study (SIREN) and mathematical model.BMJ (Clinical research ed.) · 2022Article
- Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers.Scientific reports · 2022Article
- Increased close proximity airborne transmission of the SARS-CoV-2 Delta variant.The Science of the total environment · 2022Article
- A2B-COVID: A Tool for Rapidly Evaluating Potential SARS-CoV-2 Transmission Events.Molecular biology and evolution · 2022Article
- Airborne protection for staff is associated with reduced hospital-acquired COVID-19 in English NHS trusts.The Journal of hospital infection · 2022Article
- Infection prevention and surgery in the pandemic era.Surgery (Oxford, Oxfordshire) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptomatic severe acute respiratory syndrome coronavirus 2 infection HCWs during the first wave of the COVID-19 pandemic in the UK, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). Methods: Here, we use observational data and mathematical modelling to analyse infection rates amongst HCWs working on 'red' (coronavirus disease 2019, COVID-19) and 'green' (non-COVID-19) wards during the second wave of the pandemic, before and after the substitution of filtering face piece 3 (FFP3) respirators for FRSMs. Results: Whilst using FRSMs, HCWs working on red wards faced an approximately 31-fold (and at least fivefold) increased risk of direct, ward-based infection. Conversely, after changing to FFP3 respirators, this risk was significantly reduced (52-100% protection). Conclusions: FFP3 respirators may therefore provide more effective protection than FRSMs for HCWs caring for patients with COVID-19, whether or not AGPs are undertaken. Funding: Wellcome Trust, Medical Research Council, Addenbrooke's Charitable Trust, NIHR Cambridge Biomedical Research Centre, NHS Blood and Transfusion, UKRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.