Evidence map›Paper›PMID 34783654›Full record

ArticleeLife2021

The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector.

Xiaotian Tang, Yongguo Cao, Gunjan Arora, Jesse Hwang, Andaleeb Sajid, Courtney L Brown, Sameet Mehta, Alejandro Marín-López, Yu-Min Chuang, Ming-Jie Wu and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Research square · 2026
    Article
  2. mBio · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The environment, the tick, and the pathogen - It is an ensemble.Frontiers in cellular and infection microbiology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Xiaotian Tang *Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0002-0171-9354
Yongguo Cao *Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0002-9533-7516
Gunjan AroraSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Jesse HwangSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Andaleeb SajidSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Courtney L BrownYale Combined Program in the Biological and Biomedical Sciences, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0001-7423-3331
Sameet MehtaYale Center for Genome Analysis, Yale University, New Haven, United States.
Alejandro Marín-LópezSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Yu-Min ChuangSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0003-2241-5541
Ming-Jie WuSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Hongwei MaSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, College Park, United States.
Sukanya NarasimhanSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0002-5884-6047
Yale University · USJilin University · CNUniversity of Maryland, College Park · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig · 2018 to 2026
$13.5M
IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1M
The role of tick gut microbiota in Borrelia burgdorferi transmission to miceR01AI126033 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, NARASIMHAN, SUKANYA · 2017 to 2020
$1.7M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T32 HL007974NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI126033NIDDK NIH HHS P30 DK034989
6 · The paper itself

Abstract

Adiponectin-mediated pathways contribute to mammalian homeostasis; however, little is known about adiponectin and adiponectin receptor signaling in arthropods. In this study, we demonstrate that

Indexed as

AnimalsArthropod ProteinsArthropod VectorsBorrelia burgdorferiIxodesLyme DiseasePhospholipidsReceptors, AdiponectinRNA InterferenceTranscriptomeArthropod ProteinsPhospholipidsReceptors, Adiponectinadiponectin receptorBorrelia burgdorferiinfectious diseaseIxodes scapularismicrobiologymouse

Identifiers

PMID34783654
PMCPMC8639152
OpenAlexW3212798279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.