ArticleeLife2021
Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Engineering an Exo70 integrated domain of a barley NLR for improved blast resistance.The Plant cell · 2026Article
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026Review
- Enemy's arsenal backfires: pathogen proteases detonate broad-spectrum plant immunity via engineered NLRs.Stress biology · 2026Article
- Mismatch screening in Nicotiana benthamiana to explore Pik-1/Pik-2 paired NLR platforms for receptor engineering.The New phytologist · 2026Article
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A CNL protein forms an NLR pair with NRCX to modulate plant immunity.Stress biology · 2025Article
- Genome-Wide Identification of the Glycosyl Hydrolase Family 1 Genes inPlants (Basel, Switzerland) · 2025Article
- Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector.PLoS genetics · 2025Article
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Subfunctionalization of NRC3 altered the genetic structure of the Nicotiana NRC network.PLoS genetics · 2024Article
- Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved fungal pathogen effector.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Zinc-finger (ZiF) fold secreted effectors form a functionally diverse family across lineages of the blast fungus Magnaporthe oryzae.PLoS pathogens · 2024Article
- An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function.Nature communications · 2024Article
- NLR receptors in plant immunity: making sense of the alphabet soup.EMBO reports · 2023Review
- Allelic compatibility in plant immune receptors facilitates engineering of new effector recognition specificities.The Plant cell · 2023Article
- Getting the right helper opens a new avenue for NLR engineering.The Plant cell · 2023Article
- Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens.The EMBO journal · 2023Article
- NLRscape: an atlas of plant NLR proteins.Nucleic acids research · 2023Article
- Disentangling the complex gene interaction networks between rice and the blast fungus identifies a new pathogen effector.PLoS biology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
Abstract
Cooperation between receptors from the nucleotide-binding, leucine-rich repeats (NLR) superfamily is important for intracellular activation of immune responses. NLRs can function in pairs that, upon pathogen recognition, trigger hypersensitive cell death and stop pathogen invasion. Natural selection drives specialization of host immune receptors towards an optimal response, whilst keeping a tight regulation of immunity in the absence of pathogens. However, the molecular basis of co-adaptation and specialization between paired NLRs remains largely unknown. Here, we describe functional specialization in alleles of the rice NLR pair Pik that confers resistance to strains of the blast fungus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.