ArticleAnnals of medicine2021
Higher blood urea nitrogen level is independently linked with the presence and severity of neonatal sepsis.
Article in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Prognostic significance of the blood urea nitrogen-to-serum albumin ratio in patients with septic shock.Experimental and therapeutic medicine · 2026Article
- Establishing a nomogram of the risk of in-hospital mortality in children with suspected sepsis and validating the applicability of the Phoenix.BMC pediatrics · 2026Article
- Article
- Elevated blood urea nitrogen-to-albumin ratio is associated with incident sepsis-associated delirium: evidence from a weighted competing-risk analysis in a multicenter cohort study.Frontiers in nutrition · 2026Article
- Development and validation of an explainable XGBoost model for early mortality prediction in pediatric sepsis.Frontiers in pediatrics · 2026Article
- Predictive value of combined detection of blood Urea nitrogen and Neutrophil-to-lymphocyte ratio for identifying severe pneumonia complicated with sepsis in neonates.BMC infectious diseases · 2025Article
- The ratio of blood urea nitrogen to high-density lipoprotein cholesterol: a novel risk-stratifying tool for infective endocarditis.Lipids in health and disease · 2025Article
- Development and Validation of a Risk Prediction Model for New-Onset Atrial Fibrillation in Sepsis.International journal of general medicine · 2025Article
- Sex-specific associations between blood urea nitrogen and risk of hyperuricemia in U.S. adults: the NHANES 1999-2020.Frontiers in endocrinology · 2025Article
- Significant adverse prognostic events in patients with urosepsis: a machine learning based model development and validation study.Frontiers in cellular and infection microbiology · 2025Article
- The association between blood urea nitrogen to albumin ratio and the 28 day mortality in tuberculosis patients complicated by sepsis.Scientific reports · 2024Article
- Predictive value of laboratory indicators for in-hospital death in children with community-onset sepsis: a prospective observational study of 266 patients.BMJ paediatrics open · 2024Observational
- Development and validation of an interpretable machine learning for mortality prediction in patients with sepsis.Frontiers in artificial intelligence · 2024Article
- Blood urea nitrogen to serum albumin ratio is associated with all-cause mortality in patients with AKI: a cohort study.Frontiers in nutrition · 2024Article
- Prediction of Poor Outcome Using the Urea to Albumin Ratio in Thoracic Empyema.Acta medica Lituanic · 2024Article
- A gene network database for the identification of key genes for diagnosis, prognosis, and treatment in sepsis.Scientific reports · 2023Article
- Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis.Infectious diseases and therapy · 2023Article
- A predictive model for prognosis in very low birth weight infants with late-onset sepsis.Pediatric research · 2023Article
- Exploring a global interpretation mechanism for deep learning networks when predicting sepsis.Scientific reports · 2023Article
- Tackling Neonatal Sepsis-Can It Be Predicted?International journal of environmental research and public health · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated that blood urea nitrogen (BUN) is strongly associated with sepsis. However, no data are currently available regarding the association of BUN levels and neonatal sepsis. Thus, this study aimed to investigate the role of BUN in predicting the presence and severity of neonatal sepsis.
methodsIn this study, we enrolled 925 neonates. Among them, 737 neonates were diagnosed with sepsis, including 426 neonates with severe sepsis. Neonates with hyperbilirubinemia (
resultsNeonates with sepsis and severe sepsis had a higher level of BUN. The prevalence of neonates with severe sepsis was dramatically increased according to BUN tertiles. Correlation analysis showed that BUN levels were positively correlated with the levels of infection marker procalcitonin (PCT) and high-sensitivity C-reactive protein (hsCRP). Multiple logistic regression analysis showed that BUN was an independent risk factor for the presence and severity of neonatal sepsis. ROC curve analysis showed that BUN had a well discriminatory power in predicting sepsis (area under curve (AUC) = 0.69, 95% CI, 0.66-0.74,
conclusionHigher BUN level is independently linked with the presence and severity of neonatal sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.