ReviewExperimental biology and medicine (Maywood, N.J.)2022
Emerging technologies and their impact on regulatory science.
Open access · hybridAbstract readReview
In one paragraph
Review in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations.Toxicological sciences : an official journal of the Society of Toxicology · 2024Pooled it
- Nanorobotic Approaches Against Multidrug-Resistant Infections: Design, Principle, Mechanistic Innovation, Translational Challenges and Biomedical Applications.Molecules (Basel, Switzerland) · 2026Review
- Quantitative estimates of inter-individual variability for new approach methodologies-based systemic safety toolbox using a population-based human in vitro model.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects.Archives of toxicology · 2026Article
- Article
- Microphysiological systems as an emerging in vitro approach for the evaluation of drug absorption, distribution, metabolism, and excretion and toxicity.Drug metabolism and disposition: the biological fate of chemicals · 2025Review
- Comparative Analysis of Species-Specific Hepatocyte Function and Drug Effects in a Liver Microphysiological System PhysioMimix LC12 and 96-Well Plates.ACS pharmacology & translational science · 2025Article
- Key Challenges in Plant Microbiome Research in the Next Decade.Microorganisms · 2025Review
- BRCA-CN: a blockchain-based framework to support public variant databases sharing in multi-center community for diagnostic reference and China regulatory science.Human genetics · 2025Article
- A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- From gut to liver: organoids as platforms for next-generation toxicology assessment vehicles for xenobiotics.Stem cell research & therapy · 2025Review
- AI in Histopathology Explorer for comprehensive analysis of the evolving AI landscape in histopathology.NPJ digital medicine · 2025Article
- Bridging the gap: From petri dish to patient - Advancements in translational drug discovery.Heliyon · 2025Review
- Incorporating new approach methods (NAMs) data in dose-response assessments: The future is now!Journal of toxicology and environmental health. Part B, Critical reviews · 2025Review
- Clinical translation of human iPSC technologies: advances, safety concerns, and future directions.Frontiers in cell and developmental biology · 2025Review
- Liquid biopsy in cancer management: Integrating diagnostics and clinical applications.Practical laboratory medicine · 2025Review
- Enhancing rural veterinary governance: coupling veterinary human resources with public attention to animal welfare.Frontiers in veterinary science · 2025Article
- The applications and advances of artificial intelligence in drug regulation: A global perspective.Acta pharmaceutica Sinica. B · 2025Review
- Healthcare leaders navigating complexity: a scoping review of key trends in future roles and competencies.BMC medical education · 2024Article
- Complex or not too complex? One size does not fit all in next generation microphysiological systems.iScience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 20 institutions in 12 countries.
Elke AnklamJoint Research Centre, EU.
Martin Iain BahlNational Food Institute, Technical University, Denmark.
Robert BallU.S. Food and Drug Administration.
Richard D BegerU.S. Food and Drug Administration.
Jonathan CohenU.S. Food and Drug Administration.ORCID 0000-0003-1828-5625
Suzanne FitzpatrickU.S. Food and Drug Administration.
Philippe GirardSwissmedic, Switzerland.
Blanka Halamoda-KenzaouiJoint Research Centre, EU.
Denise HintonU.S. Food and Drug Administration.
Akihiko HiroseNational Institute of Health Sciences, Japan.
Arnd HoevelerJoint Research Centre, EU.
Masamitsu HonmaNational Institute of Health Sciences, Japan.
Marta HugasEuropean Food Safety Authority, EU.
Seichi IshidaNational Institute of Health Sciences, Japan.
George En KassEuropean Food Safety Authority, EU.
Hajime KojimaNational Institute of Health Sciences, Japan.
Ira KreftingU.S. Food and Drug Administration.
Serguei LiachenkoU.S. Food and Drug Administration.
Yan LiuMedian Technologies, France.
Shane MastersU.S. Food and Drug Administration.
Uwe MarxTissUse, Germany.
Timothy McCarthyPfizer, USA.
Tim MercerGarvan Institute, Australia.
Anil PatriU.S. Food and Drug Administration.
Carmen PelaezSpanish Council for Scientific Research, Spain.
Munir PirmohamedUniversity of Liverpool, UK.
Stefan PlatzAstraZeneca, UK.
Alexandre Js RibeiroU.S. Food and Drug Administration.ORCID 0000-0002-1552-8778
Joseph V RodricksRamboll, USA.
Ivan RusynTexas A&M University, USA.
Reza M SalekInternational Agency for Research on Cancer, France.
Reinhilde SchoonjansEuropean Food Safety Authority, EU.ORCID 0000-0003-4112-8951
Primal SilvaCanadian Food Inspection Agency, Canada.
Clive N SvendsenCedars-Sinai Medical Center, USA.
Susan SumnerUniversity of North Carolina, Chapel Hill, USA.
Kyung SungU.S. Food and Drug Administration.
Danilo TagleNational Institutes of Health, USA.
Li TongUniversities of Georgia Tech and Emory, USA.
Weida TongU.S. Food and Drug Administration.
Janny van den Eijnden-van-RaaijDutch Organ-on-Chip Consortium, The Netherlands.ORCID 0000-0002-6566-5957
Neil VaryCanadian Food Inspection Agency, Canada.ORCID 0000-0003-3615-6181
Tao WangNational Medical Products Administration, China.
John WatertonUniversity of Manchester and Bioxydyn Ltd, UK.ORCID 0000-0002-7734-2290
May WangUniversities of Georgia Tech and Emory, USA.
Hairuo WenNational Institutes for Food and Drug Control, China.
David WishartUniversity of Alberta, Canada.
Yinyin YuanThe Institute of Cancer Research, UK.
William SlikkerU.S. Food and Drug Administration.ORCID 0000-0002-9616-9462
United States Food and Drug Administration · USNational Institute of Health Sciences · JPEuropean Food Safety Authority · ITJoint Research Centre · DECanadian Food Inspection Agency · CAGeorgia Institute of Technology · USAstraZeneca (United Kingdom) · GBCedars-Sinai Medical Center · USCentre international de recherche sur le cancer · FRGarvan Institute of Medical Research · AUInstitute of Cancer Research · GBNational Institutes for Food and Drug Control · CNNational Institutes of Health · USNational Medical Products Administration · CNPfizer (United States) · USSwissmedic · CHTechnical University of Denmark · DKTexas A&M University · USUniversity of Alberta · CAUniversity of Liverpool · GB
Funding
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu · 2017 to 2026
$21.2MTexas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Galen Newman · 2019 to 2026
$13.0MRTI's Regional Comprehensive Metabolomics Resource CenterU24DK097193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUMNER, SUSAN J · 2012 to 2017
$9.8MUntargeted Analysis ResourceU2CES030857 · NIEHS · RESEARCH TRIANGLE INSTITUTE · PI FENNELL, TIMOTHY RAYMOND · 2019 to 2025
$8.1MContrast-Enhanced and Image-Guided Surgery of Lung CancerR01CA163256 · NCI · EMORY UNIVERSITY · PI JO, HANJOONG, SINGHAL, SUNIL · 2011 to 2015
$6.5MEffects of opioids on reward systems in organ chipsUG3NS105703 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI SVENDSEN, CLIVE NIELS · 2017 to 2020
$5.2MPacific Northwest Advanced Compound Identification CoreU2CES030170 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI METZ, THOMAS O · 2018 to 2021
$4.6MTEX-VAL: Texas A&M Tissue Chip Validation CenterU24TR001950 · NCATS · TEXAS A&M UNIVERSITY · PI RUSYN, IVAN · 2016 to 2017
$4.2MTEX-VAL: Texas A&M Tissue Chip Validation ConsortiumU24TR002633 · NCATS · TEXAS A&M UNIVERSITY · PI RUSYN, IVAN, STEPHAN, CLIFFORD C · 2018 to 2019
$3.0MDevelopment of a Microphysiological Organ-on-Chip System to Model AmyotrophicUH3NS105703 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI SVENDSEN, CLIVE NIELS · 2021 to 2022
$2.4MA microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALSUG3TR003264 · NCATS · CEDARS-SINAI MEDICAL CENTER · PI SVENDSEN, CLIVE NIELS · 2020 to 2021
$1.6MCancer Research UK C45982/A21808NCATS NIH HHS U24 TR001950NCATS NIH HHS U24 TR002633NCATS NIH HHS UG3 TR003264NCI NIH HHS R01 CA163256NIDDK NIH HHS U24 DK097193NIEHS NIH HHS P30 ES029067NIEHS NIH HHS P42 ES027704NIEHS NIH HHS U2C ES030170NIEHS NIH HHS U2C ES030857NINDS NIH HHS UG3 NS105703NINDS NIH HHS UH3 NS105703World Health Organization 001
Abstract
There is an evolution and increasing need for the utilization of emerging cellular, molecular and
Indexed as
Biomedical ResearchComputer SimulationHumansbioimagingbioinformaticsbiomarkersEmerging technologiesregulatory sciencerisk assessment
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.