Evidence map›Paper›PMID 34783539›Full record

ArticleInorganic chemistry2021

Cyclic Analogs of Desferrioxamine E Siderophore for

Andrzej Mular, Abraham Shanzer, Henryk Kozłowski, Isabella Hubmann, Matthias Misslinger, Julia Krzywik, Clemens Decristoforo, Elzbieta Gumienna-Kontecka

Open access · hybridAbstract read
In one paragraph

Article in Inorganic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Radiometal chelators for infection diagnostics.Frontiers in nuclear medicine · 2023
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Andrzej MularFaculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.
Abraham ShanzerDepartment of Organic Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Henryk KozłowskiFaculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.
Isabella HubmannDepartment of Nuclear Medicine, Medical University Innsbruck, A-6020 Innsbruck, Austria.
Matthias MisslingerInstitute of Molecular Biology, Medical University Innsbruck, A-6020 Innsbruck, Austria.
Julia KrzywikTriMen Chemicals, Piłsudskiego 141, 92-318 Łódź, Poland.
Clemens DecristoforoDepartment of Nuclear Medicine, Medical University Innsbruck, A-6020 Innsbruck, Austria.ORCID https://orcid.org/0000-0003-0566-4036
Elzbieta Gumienna-KonteckaFaculty of Chemistry, University of Wrocław, 50-383 Wrocław, Poland.ORCID https://orcid.org/0000-0002-9556-6378
Innsbruck Medical University · ATUniversity of Wrocław · PLUniversity of Opole · PLWeizmann Institute of Science · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As multidrug-resistant bacteria are an emerging problem and threat to humanity, novel strategies for treatment and diagnostics are actively sought. We aim to utilize siderophores, iron-specific strong chelating agents produced by microbes, as gallium ion carriers for diagnosis, applying that Fe(III) can be successfully replaced by Ga(III) without losing biological properties of the investigated complex, which allows molecular imaging by positron emission tomography (PET). Here, we report synthesis, full solution chemistry, thermodynamic characterization, and the preliminary biological evaluation of biomimetic derivatives (FOX) of desferrioxamine E (FOXE) siderophore, radiolabeled with

Indexed as

Anti-Bacterial AgentsCoordination ComplexesGermaniumHydroxamic AcidsLactamsMolecular StructurePositron-Emission TomographySiderophoresStaphylococcus aureusThermodynamicsAnti-Bacterial AgentsCoordination Complexesdesferrioxamine EGermaniumHydroxamic AcidsLactamsSiderophores

Identifiers

PMID34783539
PMCPMC8653149
OpenAlexW3213509797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.