Evidence map›Paper›PMID 34783415›Full record

ArticleHuman brain mapping2022

Left parietal involvement in motion sickness susceptibility revealed by multimodal magnetic resonance imaging.

Hiroyuki Sakai, Takumi Harada, Stephen K Larroque, Athena Demertzi, Tomoko Sugawara, Taeko Ito, Yoshiro Wada, Masaki Fukunaga, Norihiro Sadato, Steven Laureys

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Hiroyuki SakaiToyota Central R&D Laboratories, Inc., Tokyo, Japan.ORCID 0000-0001-8928-6591
Takumi HaradaToyota Central R&D Laboratories, Inc., Tokyo, Japan.
Stephen K LarroqueComa Science Group, GIGA-Consciousness, GIGA Institute, University of Liège, Liège, Belgium.
Athena DemertziPhysiology of Cognition Research Lab, GIGA-Consciousness, GIGA Institute, University of Liège, Liège, Belgium.
Tomoko SugawaraToyota Central R&D Laboratories, Inc., Tokyo, Japan.
Taeko ItoDepartment of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
Yoshiro WadaDepartment of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
Masaki FukunagaDivision of Cerebral Integration, Department of System Neuroscience, National Institute for Physiological Sciences, Okazaki, Japan.
Norihiro SadatoDivision of Cerebral Integration, Department of System Neuroscience, National Institute for Physiological Sciences, Okazaki, Japan.
Steven LaureysComa Science Group, GIGA-Consciousness, GIGA Institute, University of Liège, Liège, Belgium.
Toyota Central Research and Development Laboratories (Japan) · JPUniversity of Liège · BENara Medical University · JPNational Institute for Physiological Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Susceptibility to motion sickness varies greatly across individuals. However, the neural mechanisms underlying this susceptibility remain largely unclear. To address this gap, the current study aimed to identify the neural correlates of motion sickness susceptibility using multimodal MRI. First, we compared resting-state functional connectivity between healthy individuals who were highly susceptible to motion sickness (N = 36) and age/sex-matched controls who showed low susceptibility (N = 36). Seed-based analysis revealed between-group differences in functional connectivity of core vestibular regions in the left posterior Sylvian fissure. A data-driven approach using intrinsic connectivity contrast found greater network centrality of the left intraparietal sulcus in high- rather than in low-susceptible individuals. Moreover, exploratory structural connectivity analysis uncovered an association between motion sickness susceptibility and white matter integrity in the left inferior fronto-occipital fasciculus. Taken together, our data indicate left parietal involvement in motion sickness susceptibility.

Indexed as

ConnectomeDiffusion Magnetic Resonance ImagingEcho-Planar ImagingAdultCerebral CortexDisease SusceptibilityFemaleHumansMaleMiddle AgedMotion SicknessMultimodal ImagingWhite MatterYoung Adultconflictmotion sicknessMRIresting statevestibularvisual

Identifiers

PMID34783415
PMCPMC8764490
OpenAlexW3212517910

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.