Evidence map›Paper›PMID 34783142›Full record

ArticleDepression and anxiety2022

Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study.

Jutta Joormann, Hannah N Ziobrowski, Andrew J King, Sarah M Gildea, Sue Lee, Nancy A Sampson, Stacey L House, Francesca L Beaudoin, Xinming An, Jennifer S Stevens and 35 more

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Article in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 20 institutions in 2 countries.

Jutta JoormannDepartment of Psychology, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-5531-8513
Hannah N ZiobrowskiDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Andrew J KingDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Sarah M GildeaDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Sue LeeDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Nancy A SampsonDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Francesca L BeaudoinDepartment of Emergency Medicine, The Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Xinming AnDepartment of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-4674-0314
Donglin ZengDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Thomas C NeylanDepartment of Psychiatry, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-1572-2626
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA.
Sarah D LinnstaedtDepartment of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Laura T GermineDepartment of Biomedical Engineering, Emory University, Atlanta, Georgia, USA.
Kenneth A BollenDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Scott L RauchInstitute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey, USA.
Brittany E PunchesDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Meghan E McGrathDepartment of Emergency Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Jose L PascualDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mark J SeamonPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anna M ChangDepartment of Emergency Medicine, Jefferson University Hospitals, Philadelphia, Pennsylvania, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Detroit, Massachusetts, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Robert M DomeierDepartment of Emergency Medicine, Saint Joseph Mercy Hospital, Ypsilanti, Michigan, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit, Massachusetts, USA.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-8807-0913
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, Missouri, USA.
Mark W MillerBehavioral Science Division, National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts, USA.
Robert H PietrzakClinical Neurosciences Division, National Center for PTSD, VA Connecticut Healthcare System, West Haven, Connecticut, USA.
Deanna M BarchDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.
Diego A PizzagalliDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-7772-1143
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
James M ElliottKolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Samuel A McLeanDepartment of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4831-2305
Harvard University · USUniversity of North Carolina at Chapel Hill · USEmory University · USUniversity of Florida · USUniversity of Pennsylvania · USWashington University in St. Louis · USWayne State University · USYale University · USBaystate Medical Center · USBoston Medical Center · USBoston University · USBrigham and Women's Hospital · USBrown University · USCooper Medical School of Rowan University · USGeorgia Institute of Technology · USIndiana University School of MedicineJefferson University Hospitals · USMassachusetts General Hospital · USMercy Medical Center · USNorthwestern University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Training Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9M
Early Life Stress and Depression: Molecular and Functional Imaging ApproachesR01MH095809 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, PIZZAGALLI, DIEGO A · 2012 to 2024
$6.4M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH095809NIMH NIH HHS T32 MH017119NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

backgroundA better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions.

methodsData come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders.

results27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6-7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders.

conclusionsAssessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.

Indexed as

Major Depressive DisorderStress Disorders, Post-TraumaticAccidents, TrafficDepressionHumansMotor Vehiclesmajor depressionmotor vehicle collisionposttraumatic stress disordertrauma

Identifiers

PMID34783142
PMCPMC8732322
OpenAlexW3214516280

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