ArticleJournal of general internal medicine2022
The Association Between Adverse Childhood Experiences and Positive Dementia Screen in American Older Adults.
Article in Journal of general internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Adverse childhood experiences and cognitive outcomes among older adults in low-income and middle-income countries: a systematic review.BMJ open · 2026Pooled it
- Cognitive impairment and dementia-Are they linked to childhood health and socioeconomic status? A systematic review.PloS one · 2025Pooled it
- Potentially modifiable mediators of the association between child abuse and dementia.medRxiv : the preprint server for health sciences · 2026Article
- The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of Ageing.Journal of Alzheimer's disease : JAD · 2026Article
- Childhood maltreatment confers long-term risk for cognitive impairment: A prospective investigation.The journal of prevention of Alzheimer's disease · 2025Article
- Positive Childhood Experiences, Cognition, and Biomarkers of Alzheimer's Disease.International journal of environmental research and public health · 2025Article
- Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- "Rest of the folks are tired and weary": The impact of historical lynchings on biological and cognitive health for older adults racialized as Black.Social science & medicine (1982) · 2025Article
- Lifetime chronic stress exposures, stress hormones, and biological aging: Results from the Midlife in the United States (MIDUS) study.Brain, behavior, and immunity · 2025Article
- Study on the age-period-cohort effects of cognitive abilities among older Chinese adults based on the cognitive reserve hypothesis.BMC geriatrics · 2024Article
- Allostasis, health, and development in Latin America.Neuroscience and biobehavioral reviews · 2024Review
- Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity.Neurobiology of stress · 2024Article
- No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults.The journal of prevention of Alzheimer's disease · 2024Article
- Life-Course Multidisciplinary Psychosocial Predictors of Dementia Among Older Adults: Results From the Health and Retirement Study.Innovation in aging · 2024Article
- Early life adversity as a risk factor for cognitive impairment and Alzheimer's disease.Translational neurodegeneration · 2023Review
- The Association Between Emotional Expressivity in Autobiographies from Early Adulthood and the Risk of Dementia in the Context of Written Language Skills.Journal of Alzheimer's disease reports · 2023Article
- Effect modifications of BMI transition and trajectory in the associations of adverse childhood experiences with new-onset dementia and its subtypes in older US adults.General psychiatry · 2023Article
- Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences.Microorganisms · 2022Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAdverse childhood experiences (ACEs) are linked to higher risk of common conditions driving mortality in adulthood, but little evidence exists on whether ACEs are associated with risk of dementia, a leading cause of death in the USA.
objectiveTo estimate the relationship between US adults' reported ACE scores and a positive screen for dementia.
designCross-sectional analysis of a longitudinal, national population-based survey of US older adults.
participantsSurvey respondents aged ≥ 65 years with dementia screening data from the 2017 wave of the Panel Study of Income Dynamics (PSID) and ACE scores from the 2014 PSID Childhood Retrospective Circumstances Survey supplement (1,488 eligible participants unweighted). MAIN MEASURES: Dementia screening data was collected in the 2017 wave of the PSID using the 8-item informant interview to differentiate normal cognition and dementia (AD8). Mean change in AD8 score and probability of a positive dementia screen by ACE score were calculated using adjusted regression models with post-estimation. Analyses were stratified by age group. Measures were analyzed in 2020.
resultsComplete data were available for 1,223 (82%) participants, with a mean age of 73.4 years (SD 7.1, range 65 to 96 years). Adjusted estimated probability of a positive dementia screen increased with each additional adverse childhood experience reported. Older adults with ≥ 4 ACEs had higher rates of a positive dementia screen (AD8 score ≥ 2 points) compared to those with no ACEs (adjusted rate 26.6% versus 16.3%, p = 0.034). Compared to those with no ACE history, respondents with ≥ 4 ACEs had higher odds of a 1-point increase in AD8 score across all intervals of the AD8 scale (aOR 1.79, 95% CI 1.05-3.04). The ACE-positive dementia screen associations were strongest among those aged 65-75.
conclusionsGreater exposure to ACEs is independently associated with higher probability of a positive dementia screen in older adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.