Evidence map›Paper›PMID 34782962›Full record

SynthesisSurgical endoscopy2022

Gastric ischemic conditioning prior to esophagectomy reduces anastomotic leaks and strictures: a systematic review and meta-analysis.

Uzair M Jogiat, Warren Y L Sun, Jerry T Dang, Valentin Mocanu, Janice Y Kung, Shahzeer Karmali, Simon R Turner, Noah J Switzer

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  5. Review
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  7. Article
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  10. Pilot Trial on Ischemic Conditioning of the Gastric Conduit in Esophageal Cancer: Feasibility and Impact on Anastomotic Leakage (TIGOAL-I).Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Uzair M JogiatDivision of General Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.
Warren Y L SunDivision of General Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.
Jerry T DangDivision of General Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.
Valentin MocanuDivision of General Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.
Janice Y KungJohn W. Scott Health Sciences Library, University of Alberta, Edmonton, Canada.
Shahzeer KarmaliDivision of General Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.
Simon R TurnerDivision of Thoracic Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.
Noah J SwitzerDivision of General Surgery, Department of Surgery, University of Alberta, Edmonton, Canada. nswitzer@ualberta.ca.ORCID http://orcid.org/0000-0002-9273-1008
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric ischemic conditioning (GIC) is a strategy to promote neovascularization of the gastric conduit to reduce the risk of anastomotic complications following esophagectomy. Despite a number of studies and reviews published on the concept of ischemic conditioning, there remains no clear consensus regarding its utility. We performed an updated systematic review and meta-analysis to determine the impact of GIC, particularly on anastomotic leaks, conduit ischemia, and strictures.

methodsA systematic search of MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library was performed on February 5th, 2020 by a university librarian after selection of key search terms with the research team. Inclusion criteria included human participants undergoing esophagectomy with gastric conduit reconstruction, age ≥ 18, N ≥ 5, and GIC performed prior to esophagectomy. Our primary outcome of interest was anastomotic leaks. Our secondary outcome was gastric conduit ischemia, anastomotic strictures, and overall survival. Meta-analysis was performed with RevMan 5.4.1 using a Mantel-Haenszel fixed-effects model.

resultsA total of 1712 preliminary studies were identified and 23 studies included for final review. GIC was performed in 1178 (53.5%) patients. Meta-analysis revealed reduced odds of anastomotic leaks (OR 0.67; 95% CI 0.46-0.97; I

conclusionGIC is associated with reduced odds of anastomotic leaks and anastomotic strictures and may decrease morbidity in patients undergoing esophagectomy. Further prospective randomized trials are needed to better identify the optimal patient population, timing, and techniques used to best achieve GIC.

Indexed as

Esophageal NeoplasmsEsophagectomyAnastomosis, SurgicalAnastomotic LeakConstriction, PathologicHumansIschemiaStomachAnastomotic leaksEsophagectomyGastric ischemic conditioning

Identifiers

PMID34782962
OpenAlexW3211421353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.