ArticleNature plants2021
The root meristem is shaped by brassinosteroid control of cell geometry.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 70 citations in OpenAlex.
- Synthetic activation of gibberellin signalling reveals spatial coordination of root growth.Nature plants · 2026Article
- Brassinosteroid controls leaf air space patterning non-cell autonomously by promoting epidermal growth.Development (Cambridge, England) · 2026Article
- Phase-contrast microtomography unveils mechanisms of root colonization by a vascular fungal pathogen.Nature communications · 2026Article
- Brassinosteroids control cell proliferation in the lateral root cap of the Arabidopsis root.EMBO reports · 2026Article
- AGP and EXO-LIKE genes promote brassinosteroid-dependent anisotropic growth.The New phytologist · 2026Article
- Grafting reveals organ-autonomous and feedback roles of root phloem development in source-sink dynamics.Journal of experimental botany · 2026Article
- The mechanical properties ofScience advances · 2026Article
- Correlations between surface area and volume in cell size and growth in Arabidopsis thaliana.BMC plant biology · 2026Article
- Specificity of brassinosteroid perception and its integration at signaling crossroads in vascular development.The Plant journal : for cell and molecular biology · 2025Review
- Response of hidden architects to salt stress.Planta · 2025Review
- BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19.EMBO reports · 2025Article
- Root growth and branching are enabled by brassinosteroid-regulated growth anisotropy and carbon allocation.Nature communications · 2025Article
- Distinct and redundant roles of the Arabidopsis OCTOPUS gene family in plant growth beyond phloem development.Journal of experimental botany · 2025Article
- Mechanical interactions between tissue layers underlie plant morphogenesis.Nature plants · 2025Article
- A Method to Visualize Cell Proliferation ofPlant direct · 2025Article
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- Topological analysis of 3D digital ovules identifies cellular patterns associated with ovule shape diversity.Development (Cambridge, England) · 2024Article
- The brassinosteroid receptor geneScience advances · 2024Article
- Connecting high-resolution 3D chromatin maps with cell division and cell differentiation at the root apical meristem.Plant cell reports · 2024Article
- A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context.Development (Cambridge, England) · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth extent and direction determine cell and whole-organ architecture. How they are spatio-temporally modulated to control size and shape is not well known. Here we tackled this question by studying the effect of brassinosteroid (BR) signalling on the structure of the root meristem. Quantification of the three-dimensional geometry of thousands of individual meristematic cells across different tissue types showed that the modulation of BR signalling yields distinct changes in growth rate and anisotropy, which affects the time that cells spend in the meristem and has a strong impact on the final root form. By contrast, the hormone effect on cell volume was minor, establishing cell volume as invariant to the effect of BR. Thus, BR has the highest effect on cell shape and growth anisotropy, regulating the overall longitudinal and radial growth of the meristem, while maintaining a coherent distribution of cell sizes. Moving from single-cell quantification to the whole organ, we developed a computational model of radial growth. The simulation demonstrates how differential BR-regulated growth between the inner and outer tissues shapes the meristem and thus explains the non-intuitive outcomes of tissue-specific perturbation of BR signalling. The combined experimental data and simulation suggest that the inner and outer tissues have distinct but coordinated roles in growth regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.