ArticleNature plants2021
Non-cell autonomous and spatiotemporal signalling from a tissue organizer orchestrates root vascular development.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Cell-type specific early perception of nine phytohormones revealed by single-nucleus transcriptomics in Arabidopsis.Nature communications · 2026Article
- Benchmarking plant single cell RNA-sequencing sample processing strategies.The EMBO journal · 2026Article
- Evolutionary adaptations to the hormonal regulation of vascular tissue development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Large-scale single-cell profiling of stem cells identifies redundant regulators of shoot development and yield trait variation.Developmental cell · 2025Article
- SPL13 controls a root apical meristem phase change by triggering oriented cell divisions.Science (New York, N.Y.) · 2024Article
- Nitrogen sensing and regulatory networks: it's about time and space.The Plant cell · 2024Review
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification.Plant diversity · 2024Article
- Best practices for the execution, analysis, and data storage of plant single-cell/nucleus transcriptomics.The Plant cell · 2024Article
- Spatiotemporal metabolic responses to water deficit stress in distinct leaf cell-types of poplar.Frontiers in plant science · 2024Article
- Hormonal control of the molecular networks guiding vascular tissue development in the primary root meristem of Arabidopsis.Journal of experimental botany · 2023Review
- How to explore what is hidden? A review of techniques for vascular tissue expression profile analysis.Plant methods · 2023Review
- Spatial regulation of plant hormone action.Journal of experimental botany · 2023Review
- Exploring the identity of individual plant cells in space and time.The New phytologist · 2023Review
- Application of single-cell multi-omics approaches in horticulture research.Molecular horticulture · 2023Review
- microRNA165 and 166 modulate response of the Arabidopsis root apical meristem to salt stress.Communications biology · 2023Article
- A redundant transcription factor network steers spatiotemporal Arabidopsis triterpene synthesis.Nature plants · 2023Article
- The transcription factor AtMYB12 is part of a feedback loop regulating cell division orientation in the root meristem vasculature.Journal of experimental botany · 2023Article
- Molecular Mechanisms Underlying the Establishment and Maintenance of Vascular Stem Cells in Arabidopsis thaliana.Plant & cell physiology · 2023Review
- Cytokinins - regulators ofFrontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 3 countries.
Funding
Abstract
During plant development, a precise balance of cytokinin is crucial for correct growth and patterning, but it remains unclear how this is achieved across different cell types and in the context of a growing organ. Here we show that in the root apical meristem, the TMO5/LHW complex increases active cytokinin levels via two cooperatively acting enzymes. By profiling the transcriptomic changes of increased cytokinin at single-cell level, we further show that this effect is counteracted by a tissue-specific increase in CYTOKININ OXIDASE 3 expression via direct activation of the mobile transcription factor SHORTROOT. In summary, we show that within the root meristem, xylem cells act as a local organizer of vascular development by non-autonomously regulating cytokinin levels in neighbouring procambium cells via sequential induction and repression modules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.