Evidence map›Paper›PMID 34782728›Full record

ArticleNature human behaviour2022

Developmental differences in memory reactivation relate to encoding and inference in the human brain.

Margaret L Schlichting, Katharine F Guarino, Hannah E Roome, Alison R Preston

Abstract read
In one paragraph

Article in Nature human behaviour, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Neural Representations of Reward-Related Memories Shift across Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
  6. Article
  7. Striatal and hippocampal contributions to value-based learning in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  8. Article
  9. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Margaret L SchlichtingDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada. meg.schlichting@utoronto.ca.ORCID http://orcid.org/0000-0002-5433-8870
Katharine F GuarinoDepartment of Psychology, Loyola University Chicago, Chicago, IL, USA.
Hannah E RoomeCenter for Learning & Memory, The University of Texas at Austin, Austin, TX, USA.
Alison R PrestonCenter for Learning & Memory, The University of Texas at Austin, Austin, TX, USA. apreston@utexas.edu.ORCID http://orcid.org/0000-0003-2706-6862

Funding

Hippocampal and prefrontal contributions to memory integrationR01MH100121 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Alison R Preston · 2013 to 2026
$7.3M
Linking the neurobiological development of memory and reasoningR21HD083785 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI PRESTON, ALISON R · 2016 to 2017
$423k
NICHD NIH HHS R21 HD083785NIMH NIH HHS R01 MH100121
6 · The paper itself

Abstract

Despite the fact that children can draw on their memories to make novel inferences, it is unknown whether they do so through the same neural mechanisms as adults. We measured memory reinstatement as participants aged 7-30 years learned new, related information. While adults brought memories to mind throughout learning, adolescents did so only transiently, and children not at all. Analysis of trial-wise variability in reactivation showed that discrepant neural mechanisms-and in particular, what we interpret as suppression of interfering memories during learning in early adolescence-are nevertheless beneficial for later inference at each developmental stage. These results suggest that while adults build integrated memories well-suited to informing inference directly, children and adolescents instead must rely on separate memories to be individually referenced at the time of inference decisions.

Indexed as

BrainLearningAdolescentAdultBrain MappingChildHumansYoung Adult

Identifiers

PMID34782728
PMCPMC8973118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.