SynthesisMolecular psychiatry2022
Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Alterations in resting-state brain activity patterns following antidepressant treatment: insights from a coordinate-based meta-analysis.Psychological medicine · 2025Pooled it
- Pooled it
- Identification of risk loci for postpartum depression in a genome-wide association study.Psychiatry and clinical neurosciences · 2024Pooled it
- The genetic overlap between schizophrenia and major depression with cognitive function.Molecular psychiatry · 2026Article
- Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods.Chinese medicine · 2026Review
- Associations of self-management behaviors, depressive symptoms, and glycemic control on cognitive function in rural elderly with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.Translational psychiatry · 2025Review
- The relationship between social isolation, depressive symptoms and cognitive function in older adults: a longitudinal mediation study in China.Social psychiatry and psychiatric epidemiology · 2025Article
- The independent role of fine particulate matter and genetic liability on cognition in older adults.Annals of general psychiatry · 2025Article
- Associations between Kynurenine pathway metabolites and cognitive dysfunction in major depressive disorder.PloS one · 2025Article
- Cognitive impairment and depression precede increased HDL-C levels in middle-aged and older Chinese adults: cross-lagged panel analyses.Lipids in health and disease · 2024Article
- The MIND diet, brain transcriptomic alterations, and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort.The Journal of nutrition · 2024Article
- The ROSMAP project: aging and neurodegenerative diseases through omic sciences.Frontiers in neuroinformatics · 2024Review
- Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence.Neurobiology of disease · 2024Article
- Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain.Translational psychiatry · 2023Article
- Whole Genome Sequencing Revealed Inherited Rare Oligogenic Variants Contributing to Schizophrenia and Major Depressive Disorder in Two Families.International journal of molecular sciences · 2023Article
- The MIND diet, brain transcriptomic alterations, and dementia.medRxiv : the preprint server for health sciences · 2023Article
- Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents.Translational psychiatry · 2023Article
- Discovery and replication of blood-based proteomic signature of PTSD in 9/11 responders.Translational psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 10 institutions in 3 countries.
Anbupalam Thalamuthu *Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Natalie T Mills *Discipline of Psychiatry, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0003-3255-5118
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Heike MinnerupInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Nils OpelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Jonathan ReppleInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Marius GruberInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg - UKGM Marburg, Marburg, Germany.
Frederike SteinDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg - UKGM Marburg, Marburg, Germany.
Katharina BroschDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg - UKGM Marburg, Marburg, Germany.
Tina MellerDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg - UKGM Marburg, Marburg, Germany.
Julia-Katharina PfarrDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg - UKGM Marburg, Marburg, Germany.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-1876-6368
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8770-2464
Stephanie WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg - UKGM Marburg, Marburg, Germany.
Mark AdamsDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3599-6018
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0003-1249-6106
Ian J DearyDepartment of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-1733-263X
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-9405-9550
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0003-0198-5078
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-3684-4208
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Sandra van der Auwera-PalitschkaDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-1757-7768
K Oliver SchubertDiscipline of Psychiatry, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0003-1690-0209
Bernhard T BauneDiscipline of Psychiatry, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia. Bernhard.Baune@ukmuenster.de.
University of Münster · DEPhilipps University of Marburg · DEUniversitätsmedizin Greifswald · DEUniversity of Bonn · DEUniversity of Edinburgh · GBWestern General Hospital · GBHeidelberg University · DEThe University of Adelaide · AUThe University of Melbourne · AUUNSW Sydney · AU
Funding
Chief Scientist Office CZD/16/6Medical Research Council MC_PC_17209Medical Research Council MC_UU_00007/10Medical Research Council MR/K026992/1Wellcome Trust 104036Wellcome Trust 216767Wellcome Trust 220857
Abstract
Major Depressive Disorder (MDD) often is associated with significant cognitive dysfunction. We conducted a meta-analysis of genome-wide interaction of MDD and cognitive function using data from four large European cohorts in a total of 3510 MDD cases and 6057 controls. In addition, we conducted analyses using polygenic risk scores (PRS) based on data from the Psychiatric Genomics Consortium (PGC) on the traits of MDD, Bipolar disorder (BD), Schizophrenia (SCZ), and mood instability (MIN). Functional exploration contained gene expression analyses and Ingenuity Pathway Analysis (IPA
Indexed as
Major Depressive DisorderCognitionDepressionGenetic Predisposition to DiseaseGenome-Wide Association StudyGuanine Nucleotide Exchange FactorsHumansMultifactorial InheritanceNerve Tissue ProteinsPolymorphism, Single NucleotideReceptors, ImmunologicARFGEF1 protein, humanGuanine Nucleotide Exchange FactorsNerve Tissue ProteinsReceptors, Immunologic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.