Evidence map›Paper›PMID 34782708›Full record

Trial reportScientific reports2021

Safety and efficacy of 0.02% and 0.01% atropine on controlling myopia progression: a 2-year clinical trial.

Can Cui, Xiujuan Li, Yong Lyu, Li Wei, Bingxin Zhao, Shiao Yu, Junbo Rong, Yanhui Bai, Aicun Fu

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Dose-Dependent Effects of Atropine on Accommodative and Binocular Visual Function for Myopia Control in Children: A Systematic Review and Meta-Analysis.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
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  8. Effect of low-dose atropine eyedrops on pupil metrics: results after half a year of treatment and cessation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
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  17. Retardation of myopia by atropine regimes.International journal of ophthalmology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Can Cui *The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Xiujuan Li *The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Yong LyuThe First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Li WeiThe First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Bingxin ZhaoThe First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Shiao YuThe First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Junbo RongThe First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Yanhui BaiThe First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China.
Aicun FuThe First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450000, China. fuaicun2019@qq.com.
First Affiliated Hospital of Zhengzhou University · CN

Funding

Health and Family Planning Science and Technology Talents Overseas Training Project of Henan Province 2018038Key Research and Promotion Special Projects of Henan Provincial Science and Technology Department 201801591Key School Research Projects of Henan Provincial Department of Education 19A320066Medical Science and Technology Research Projects of Henan Province Health Commission 201602073
6 · The paper itself

Abstract

Four hundred myopic children randomly received atropine 0.02% (n = 138) or 0.01% (n = 142) in both eyes once-nightly or only wore single-vision spectacles (control group) (n = 120) for 2 years. Spherical equivalent refractive error (SER), axial length (AL), pupil diameter (PD), and amplitude of accommodation (AMP) were measured every 4 months. After 2 years, the SER changes were - 0.80 (0.52) D, - 0.93 (0.59) D and - 1.33 (0.72) D and the AL changes were 0.62 (0.29) mm, 0.72 (0.31) mm and 0.88 (0.35) mm in the 0.02% and 0.01% atropine groups and control group, respectively. There were significant differences between changes in SER and AL in the three groups (all P < 0.001). The changes in SER and AL in the 2nd year were similar to the changes in the 1st year in the three groups (all P > 0.05). From baseline to 2 years, the overall decrease in AMP and increase in PD were not significantly different in the two atropine groups, whereas the AMP and PD in the control group remained stable (all P > 0.05). 0.02% atropine had a better effect on myopia control than 0.01% atropine, and its effects on PD and AMP were similar to 0.01% atropine. 0.02% or 0.01% atropine controlled myopia progression and AL elongation synchronously and had similar effects on myopia control each year.

Indexed as

AtropineCase-Control StudiesChildDisease ManagementFemaleHumansMaleMydriaticsMyopia, DegenerativeRefraction, OcularTreatment OutcomeAtropineMydriatics

Identifiers

PMID34782708
PMCPMC8592985
OpenAlexW3213114377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.