Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Rostral anterior cingulate network effective connectivity in depressed adolescents and associations with treatment response in a randomized controlled trial.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Potential Targets for Scalp Acupuncture and Brain Stimulation in Mental Disorders: Evidence From Large-Scale Meta-Analyses.Alpha psychiatry · 2026Pooled it
- Major depressive disorder associated alterations in the effective connectivity of the face processing network: a systematic review.Translational psychiatry · 2024Pooled it
- Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis.Stroke and vascular neurology · 2026Article
- Anterior Cingulate Cortex Reactivity to Social Stimuli Marks Individual Differences to Peer Victimization on Internalizing Symptoms in Adolescence.JAACAP open · 2026Article
- Cerebellar-Basal Ganglia Dysconnectivity in Schizophrenia: Insights into Motivational Deficits.Schizophrenia bulletin · 2026Article
- Exercise-induced anandamide-CB1R signaling and prefrontal-amygdala stress circuits in adolescent depression: a critical hypothesis-driven narrative review.Frontiers in psychiatry · 2026Review
- Wired to Regulate: Brain Connectivity Predicts Emotion Regulation Capacity and Tendency.Human brain mapping · 2025Article
- Causal structural covariance network identifies progressive gray matter atrophy in adolescents with major depressive disorder.Psychological medicine · 2025Article
- Disruptions in Cognitive-Affective Circuitry in Major Depression Disorder: Insights From REST-Meta-MDD and Its Implication for Predicting TMS Treatment Efficacy.CNS neuroscience & therapeutics · 2025Article
- Exploring the capabilities of repetitive transcranial magnetic stimulation in major depressive disorder: Dynamic causal modeling of the neural network.Translational psychiatry · 2025Article
- Graded changes in local functional connectivity of the cerebral cortex in young people with depression.Psychological medicine · 2025Article
- Disorganization of Small-World Functional Brain Networks in First-Episode, Treatment-Naïve Adolescents With Major Depressive Disorder.Brain and behavior · 2025Article
- Task-induced deactivation dysfunction during reward processing is associated with low self-esteem in a possible subtype of major depression.Brain and behavior · 2024Article
- Resting-state effective connectivity is systematically linked to reappraisal success of high- and low-intensity negative emotions.Human brain mapping · 2024Article
- Altered task-related decoupling of the rostral anterior cingulate cortex in depression.NeuroImage. Clinical · 2024Article
- Emotion-related impulsivity and suicidal ideation and behavior in schizophrenia spectrum disorder: a pilot fMRI study.Frontiers in psychiatry · 2024Article
- Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression.Frontiers in psychiatry · 2024Article
- A brain model of altered self-appraisal in social anxiety disorder.Translational psychiatry · 2023Article
- Social threat, fronto-cingulate-limbic morphometry, and symptom course in depressed adolescents: a longitudinal investigation.Psychological medicine · 2023Article
- Altered Neurovascular Coupling for Multidisciplinary Intensive Rehabilitation in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rostral anterior cingulate cortex (rACC) is consistently implicated in the neurobiology of depression. While the functional connectivity of the rACC has been previously associated with treatment response, there is a paucity of work investigating the specific directional interactions underpinning these associations. We compared the fMRI resting-state effective connectivity of 94 young people with major depressive disorder and 91 healthy controls. Following the fMRI scan, patients were randomized to receive cognitive behavioral therapy for 12 weeks, plus either fluoxetine or a placebo. Using spectral dynamic causal modelling, we examined the effective connectivity of the rACC with eight other regions implicated in depression: the left and right anterior insular cortex (AIC), amygdalae, and dorsolateral prefrontal cortex (dlPFC); and in the midline, the subgenual (sgACC) and dorsal anterior cingulate cortex (dACC). Parametric empirical Bayes was used to compare baseline differences between controls and patients and responders and non-responders to treatment. Depressed patients demonstrated greater inhibitory connectivity from the rACC to the dlPFC, AIC, dACC and left amygdala. Moreover, treatment responders illustrated greater inhibitory connectivity from the rACC to dACC, greater excitatory connectivity from the dACC to sgACC and reduced inhibitory connectivity from the sgACC to amygdalae at baseline. The inhibitory hyperconnectivity of the rACC in depressed patients aligns with hypotheses concerning the dominance of the default mode network over other intrinsic brain networks. Surprisingly, treatment responders did not demonstrate connectivity which was more similar to healthy controls, but rather distinct alterations that may have predicated their enhanced treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.