ArticleScientific reports2021
Development of FRET-based indicators for visualizing homophilic trans interaction of a clustered protocadherin.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Single Cell Mechanics in Disease Progression.Small science · 2026Review
- Fluorescent indicators for visualizing dynamic contact between cells and between processes originating from a single cell.Cell reports methods · 2026Article
- Visualization ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Visualization ofiScience · 2023Article
- Development of intensiometric indicators for visualizing N-cadherin interaction across cells.Communications biology · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Clustered protocadherins (Pcdhs), which are cell adhesion molecules, play a fundamental role in self-recognition and non-self-discrimination by conferring diversity on the cell surface. Although systematic cell-based aggregation assays provide information regarding the binding properties of Pcdhs, direct visualization of Pcdh trans interactions across cells remains challenging. Here, we present Förster resonance energy transfer (FRET)-based indicators for directly visualizing Pcdh trans interactions. We developed the indicators by individually inserting FRET donor and acceptor fluorescent proteins (FPs) into the ectodomain of Pcdh molecules. They enabled successful visualization of specific trans interactions of Pcdh and revealed that the Pcdh trans interaction is highly sensitive to changes in extracellular Ca
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