Evidence map›Paper›PMID 34782600›Full record

ArticleNature communications2021

Detrimental proarrhythmogenic interaction of Ca

Philipp Bengel, Nataliya Dybkova, Petros Tirilomis, Shakil Ahmad, Nico Hartmann, Belal A Mohamed, Miriam Celine Krekeler, Wiebke Maurer, Steffen Pabel, Maximilian Trum and 10 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. MOG1medRxiv : the preprint server for health sciences · 2025
    Article
  7. Article
  8. Article
  9. Blocking NaBMC cardiovascular disorders · 2024
    Article
  10. NaInternational journal of molecular sciences · 2024
    Article
  11. Mechanisms of torsades de pointes: an update.Frontiers in cardiovascular medicine · 2024
    Review
  12. CaMKIIδ-dependent dysregulation of atrial NaFrontiers in pharmacology · 2024
    Article
  13. Review
  14. Article
  15. Molecular and Functional Relevance of NaInternational journal of molecular sciences · 2023
    Article
  16. Review
  17. Changes in cellular CaThe Journal of physiology · 2023
    Article
  18. CaMKII as a Therapeutic Target in Cardiovascular Disease.Annual review of pharmacology and toxicology · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Philipp Bengel *Clinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-7616-180X
Nataliya Dybkova *Clinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Petros Tirilomis *Clinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Shakil AhmadClinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Nico HartmannClinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Belal A MohamedClinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Miriam Celine KrekelerClinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Wiebke MaurerClinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Steffen PabelClinic and Polyclinic for Internal Medicine II, University Medical Centre Regensburg, Regensburg, Germany.
Maximilian TrumClinic and Polyclinic for Internal Medicine II, University Medical Centre Regensburg, Regensburg, Germany.
Julian MustrophClinic and Polyclinic for Internal Medicine II, University Medical Centre Regensburg, Regensburg, Germany.
Jan GummertHeart and Diabetes Centre North Rhine-Westphalia, Bad Oeynhausen, Germany.
Hendrik MiltingHeart and Diabetes Centre North Rhine-Westphalia, Bad Oeynhausen, Germany.
Stefan WagnerClinic and Polyclinic for Internal Medicine II, University Medical Centre Regensburg, Regensburg, Germany.
Senka Ljubojevic-HolzerDepartment of Cardiology, Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0001-6994-9976
Karl ToischerClinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Lars S MaierClinic and Polyclinic for Internal Medicine II, University Medical Centre Regensburg, Regensburg, Germany.
Gerd HasenfussClinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.
Katrin Streckfuss-Bömeke *Clinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5137-7228
Samuel Sossalla *Clinic for Cardiology & Pneumology, Georg-August University Göttingen, Göttingen, Germany. Samuel.Sossalla@klinik.uni-regensburg.de.ORCID http://orcid.org/0000-0001-8034-2673
German Centre for Cardiovascular Research · DEUniversity Hospital Regensburg · DEHeart and Diabetes Center North Rhine-Westphalia · DEMedical University of Graz · ATUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An interplay between Ca

Indexed as

AnimalsArrhythmias, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2CRISPR-Cas SystemsHeart FailureHomeostasisHumansMiceMice, KnockoutMice, TransgenicMolecular MedicineMyocytes, CardiacNAV1.8 Voltage-Gated Sodium ChannelCalcium-Calmodulin-Dependent Protein Kinase Type 2NAV1.8 Voltage-Gated Sodium ChannelSCN10A protein, humanScn10a protein, mouse

Identifiers

PMID34782600
PMCPMC8593192
OpenAlexW3211976171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.