Evidence map›Paper›PMID 34782594›Full record

ArticleTranslational psychiatry2021

Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues.

Gauri Ang, Laurence A Brown, Shu K E Tam, Kay E Davies, Russell G Foster, Paul J Harrison, Rolf Sprengel, Vladyslav V Vyazovskiy, Peter L Oliver, David M Bannerman and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Gauri Ang *Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Laurence A Brown *Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Shu K E Tam *Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3419-896X
Kay E DaviesDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Russell G FosterSleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6055-2067
Paul J HarrisonDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-6719-1126
Rolf SprengelResearch Group of the Max Planck Institute for Medical Research at the Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3370-0970
Vladyslav V VyazovskiyDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4336-6681
Peter L OliverDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. p.oliver@har.mrc.ac.uk.
David M BannermanDepartment of Experimental Psychology, University of Oxford, Oxford, UK. david.bannerman@psy.ox.ac.uk.ORCID http://orcid.org/0000-0002-3024-7595
Stuart N PeirsonSleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. stuart.peirson@eye.ox.ac.uk.
University of Oxford · GBHeidelberg University · DEWarneford Hospital · GB

Funding

Medical Research Council MR/L003635/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/V000977/1Wellcome Trust 087736
6 · The paper itself

Abstract

Dysfunction of the glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit and deficits in synaptic plasticity are implicated in schizophrenia and sleep and circadian rhythm disruption. To investigate the role of GluA1 in circadian and sleep behaviour, we used wheel-running, passive-infrared, and video-based home-cage activity monitoring to assess daily rest-activity profiles of GluA1-knockout mice (Gria1

Indexed as

Circadian RhythmReceptors, AMPAalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCuesMiceSuprachiasmatic Nucleusalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidReceptors, AMPA

Identifiers

PMID34782594
PMCPMC8593011
OpenAlexW3212691947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.