Evidence map›Paper›PMID 34782577›Full record

ArticleNeural regeneration research2022

Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury.

Yi-Xin Wang, Jin-Zhu Bai, Zhen Lyu, Guang-Hao Zhang, Xiao-Lin Huo

Abstract read
In one paragraph

Article in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi-Xin WangDepartment of Spine and Spinal Cord Surgery, Beijing Bo'ai Hospital, Rehabilitation Research Center; School of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Jin-Zhu BaiDepartment of Spine and Spinal Cord Surgery, Beijing Bo'ai Hospital, Rehabilitation Research Center; School of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Zhen LyuDepartment of Spine and Spinal Cord Surgery, Beijing Bo'ai Hospital, Rehabilitation Research Center; School of Rehabilitation Medicine, Capital Medical University, Beijing, China.
Guang-Hao ZhangBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences; School of Electronics, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China.
Xiao-Lin HuoBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences; School of Electronics, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS. The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks. The underlying mechanism may be related to the effects of OFS on promoting axon regeneration, inhibiting astrocyte proliferation, and improving the linear arrangement of astrocytes. This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University (supplemental approval No. AEEI-2021-204) on July 26, 2021.

Indexed as

astrocyte orientationastrocyte proliferationaxonal regenerationlocomotor recoveryneural regenerationneural repairoscillating field stimulationspinal cord injurystimulus duration

Identifiers

PMID34782577
PMCPMC8643069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.