Evidence map›Paper›PMID 34782551›Full record

ReviewNeural regeneration research2022

Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling.

Bart Nieuwenhuis, Richard Eva

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Bart NieuwenhuisJohn van Geest Center for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Richard EvaJohn van Geest Center for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Richard Wolf (Germany) · DEUniversity of Cambridge · GB

Funding

Medical Research Council MR/R004463/1Medical Research Council MR/R004544/1Medical Research Council MR/V002694/1
6 · The paper itself

Abstract

Much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous system. Axons in the central nervous system fail to regenerate, meaning that injuries or diseases that cause loss of axonal connectivity have life-changing consequences. In 2008, genetic deletion of PTEN was identified as a means of stimulating robust regeneration in the optic nerve. PTEN is a phosphatase that opposes the actions of PI3-kinase, a family of enzymes that function to generate the membrane phospholipid PIP

Indexed as

axon cytoskeletonaxon regenerationaxon transportcell signalingcentral nervous systemgrowth coneneuroprotectionPI3KPI3-kinasePTENtraffickingtranscriptiontranslation

Identifiers

PMID34782551
PMCPMC8643051
OpenAlexW3213144231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.