Evidence map›Paper›PMID 34782459›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population.

Andrey K Shevchenko, Daria V Zhernakova, Sergey V Malov, Alexey Komissarov, Sofia M Kolchanova, Gaik Tamazian, Alexey Antonik, Nikolay Cherkasov, Sergey Kliver, Anastasiia Turenko and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Antiretroviral therapy blocks natural selection on protective and disease-susceptible HLA-B alleles in HIV-1 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Legacy of a magic gene-Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 5 countries.

Andrey K ShevchenkoLaboratory of Genomic Diversity, Center for Computer Technologies, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), 197101 St. Petersburg, Russia.
Daria V ZhernakovaLaboratory of Genomic Diversity, Center for Computer Technologies, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), 197101 St. Petersburg, Russia.
Sergey V MalovTheodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, 199034 St. Petersburg, Russia; sofiia.kolchanova@gmail.com lgdchief@gmail.com.ORCID 0000-0003-0093-6506
Alexey KomissarovApplied Genomics Laboratory, Solution Chemistry of Advanced Materials and Technologies Institute, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), 197101 St. Petersburg, Russia.
Sofia M KolchanovaLaboratory of Genomic Diversity, Center for Computer Technologies, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), 197101 St. Petersburg, Russia; sofiia.kolchanova@gmail.com lgdchief@gmail.com.ORCID 0000-0002-1928-5486
Gaik TamazianTheodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, 199034 St. Petersburg, Russia.
Alexey AntonikTheodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, 199034 St. Petersburg, Russia.
Nikolay CherkasovTheodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, 199034 St. Petersburg, Russia.
Sergey KliverInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Anastasiia TurenkoLaboratory of Genomic Diversity, Center for Computer Technologies, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), 197101 St. Petersburg, Russia.
Mikhail RotkevichTheodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, 199034 St. Petersburg, Russia.
Igor EvsyukovLaboratory of Genomic Diversity, Center for Computer Technologies, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), 197101 St. Petersburg, Russia; sofiia.kolchanova@gmail.com lgdchief@gmail.com.ORCID 0000-0003-1810-429X
David VlahovYale University School of Nursing, Yale University, West Haven, CT 06477; sofiia.kolchanova@gmail.com lgdchief@gmail.com.ORCID 0000-0002-3449-8068
Prisca K ThamiDivision of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, 7925 Cape Town, South Africa.
Simani GaseitsiweBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Vladimir NovitskyBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Myron EssexBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Stephen J O'BrienLaboratory of Genomic Diversity, Center for Computer Technologies, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), 197101 St. Petersburg, Russia; sofiia.kolchanova@gmail.com lgdchief@gmail.com.ORCID 0000-0001-7857-0757
St Petersburg University · RUITMO University · RUBotswana Harvard AIDS Institute Partnership · BWBrown University · USSiberian Branch of the Russian Academy of Sciences · RUUniversity Medical Center Groningen · NLUniversity of Cape Town · ZAYale University · US

Funding

Wellcome TrustWellcome Trust 107752/Z/15/Z
6 · The paper itself

Abstract

Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (

Indexed as

Genetic VariationGenome-Wide Association StudyAcquired Immunodeficiency SyndromeAdaptor Protein Complex 3Adaptor Protein Complex beta SubunitsBotswanaGenotypeHIV InfectionsHumansNerve Tissue ProteinsReceptor-Like Protein Tyrosine Phosphatases, Class 4Receptors, Cell SurfaceAdaptor Protein Complex 3Adaptor Protein Complex beta SubunitsAP3B1 protein, humanNEO1 protein, humanNerve Tissue ProteinsPTPRA protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 4Receptors, Cell SurfaceAIDSBotswanaGWASGWATCHHIV-C

Identifiers

PMID34782459
PMCPMC8672799
OpenAlexW3214270518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.