Trial reportNeurology2022
Cerebral Microbleeds and Treatment Effect of Intravenous Thrombolysis in Acute Stroke: An Analysis of the WAKE-UP Randomized Clinical Trial.
Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01525290 (Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke: a Randomised, Double-blind, Placebo-controlled Trial
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Comparative Diagnostic and Prognostic Performance of SWI and T2-Weighted MRI in Cerebral Microbleed Detection Following Acute Ischemic Stroke: A Meta-Analysis and SPOT-CMB Study.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke.JAMA network open · 2025Trial
- New remote cerebral microbleeds in acute ischemic stroke: an analysis of the randomized, placebo-controlled WAKE-UP trial.Journal of neurology · 2022Trial
- Beyond proportional recovery in wake-up stroke: unsupervised recovery clusters based on the NIHSS.Journal of neuroengineering and rehabilitation · 2026Article
- Carotid intraplaque neovascularization and cerebral microbleeds: correlation assessed by plane-wave ultrasensitive flow imaging.Frontiers in neurology · 2026Article
- Clinical Management of Cerebral Amyloid Angiopathy.Journal of clinical medicine · 2025Review
- Cerebrovascular Management Considerations in Patients on AATs.Journal of clinical medicine · 2025Review
- Thrombolysis for acute ischaemic stroke: development and update.Brain communications · 2025Review
- Admission NIHSS score and diabetes as independent predictors of in-hospital early neurological improvement following mechanical thrombectomy: a retrospective cohort study.Frontiers in neurology · 2025Article
- Cerebral small vessel disease was associated with the prognosis in ischemic stroke with atrial fibrillation.CNS neuroscience & therapeutics · 2024Article
- Article
- Acute cerebral microbleeds detected on high resolution head CT presenting with transient neurologic events.Cerebral circulation - cognition and behavior · 2024Article
- Article
- Ischemic Stroke and Cerebral Microbleeds: A Two-Sample Bidirectional Mendelian Randomization Study.Neurology and therapy · 2023Article
- Advances in differential diagnosis of cerebrovascular diseases in magnetic resonance imaging: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Exploring the Impact of Cerebral Microbleeds on Stroke Management.Neurology international · 2023Review
- Cerebral small vessel disease and intracranial bleeding risk: Prognostic and practical significance.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Magnetic Resonance Imaging or Computed Tomography for Suspected Acute Stroke: Association of Admission Image Modality with Acute Recanalization Therapies, Workflow Metrics, and Outcomes.Annals of neurology · 2022Observational
- A novel rat model for cerebral venous sinus thrombosis: verification of similarity to human disease via clinical analysis and experimental validation.Journal of translational medicine · 2022Article
Corrections and comments
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Authors and funding
23 authors at 1 institution in 1 country.
Ludwig SchlemmFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0003-4165-2366
Tim Bastian BraemswigFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0001-6112-2800
Florent BoutitieFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Jan VynckierFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0001-5338-961X
Märit JensenFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0001-7793-0941
Ivana GalinovicFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Claus Z SimonsenFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Bastian ChengFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Tae-Hee ChoFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Jens FiehlerFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0001-8533-7478
Josep PuigFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Vincent ThijsFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0002-6614-8417
Jochen FiebachFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0002-7936-6958
Keith MuirFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0001-9535-022X
Norbert NighoghossianFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Martin EbingerFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Salvador PedrazaFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Götz ThomallaFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Christian GerloffFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Matthias EndresFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.
Robin LemmensFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium.ORCID 0000-0002-4948-5956
Christian H NolteFrom the Klinik und Hochschulambulanz für Neurologie (L.S., T.B.B., M. Endres, C.H.N.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin, and Berlin Institute of Health; Center for Stroke Research Berlin (L.S., T.B.B., I.G., J. Fiebach, M. Ebinger, M. Endres, C.H.N.), Charité-Universitätsmedizin; Berlin Institute of Health (L.S., T.B.B., M. Endres, C.H.N.), Germany; Hospices Civils de Lyon (F.B.), Service de Biostatistique; Université Lyon 1 and Centre National de la Recherche Scientifique (F.B.), UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France; Department of Neurology (J.V.), University Hospital Bern, Switzerland; Klinik und Poliklinik für Neurologie (M.J., B.C., G.T., C.G.), Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Diagnostic and Interventional Neuroradiology (J. Fiehler), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiology (J.P., S.P.), Doctor Josep Trueta University Hospital, Department of Radiology (IDI) (J.P., S.P.), Girona Biomedical Research Institute (IDIBGI), Spain; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Institute of Neuroscience and Psychology, University of Glasgow (K.M.), UK; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (M. Ebinger), Medical Park Berlin Humboldtmühle; German Center for Cardiovascular Research (DZHK) (M. Endres, C.H.N.), Partner Site Berlin; German Center for Neurodegenerative Diseases (DZNE) (M. Endres, C.H.N.), Partner Site Berlin; ExcellenceCluster NeuroCure (M. Endres), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (R.L.), University Hospitals Leuven, Belgium; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; and VIB-KU Leuven Center for Brain and Disease Research (R.L.), Laboratory of Neurobiology, Leuven, Belgium. christian.nolte@charite.de.ORCID 0000-0001-5577-1775
WAKE-UP Investigators
Humboldt-Universität zu Berlin · DE
Funding
Medical Research Council MR/N003403/1
Abstract
BACKGROUND AND
objectivesCerebral microbleeds (CMBs) are common in patients with acute ischemic stroke and are associated with increased risk of intracerebral hemorrhage (ICH) after intravenous thrombolysis. Whether CMBs modify the treatment effect of thrombolysis is unknown.
methodsWe performed a prespecified analysis of the prospective randomized controlled multicenter Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke (WAKE-UP) trial including patients with acute ischemic stroke with unknown time of symptom onset and diffusion-weighted imaging-fluid-attenuated inversion recovery mismatch on MRI receiving alteplase or placebo. Patients were screened and enrolled between September 2012 and June 2017 (with final follow-up in September 2017). Patients were randomized to treatment with IV thrombolysis with alteplase at 0.9 mg/kg body weight or placebo. CMB status (presence, number, and distribution) was assessed after study completion by 3 raters blinded to clinical information following a standardized protocol. Outcome measures were excellent functional outcome at 90 days, defined by modified Rankin Scale (mRS) score ≤1, and symptomatic ICH according to National Institutes of Neurological Disease and Stroke trial criteria 22 to 36 hours after treatment.
resultsOf 503 patients enrolled in the WAKE-UP trial, 459 (91.3%; 288 [63%] men) were available for analysis. Ninety-eight (21.4%) had at least 1 CMB on baseline imaging; 45 (9.8%) had exactly 1 CMB; 37 (8.1%) had 2 to 4 CMBs; and 16 (3.5%) had ≥5 CMBs. Presence of CMBs was associated with a nonsignificant increased risk of symptomatic ICH (11.2% vs 4.2%; adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 0.99-5.43, DISCUSSION: In the randomized-controlled WAKE-UP trial, we saw no evidence of reduced treatment effect of alteplase in patients with acute ischemic stroke with ≥1 CMBs. Additional studies are needed to determine the treatment effect of alteplase and its benefit-harm ratio in patients with a larger number of CMBs. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov identifier NCT01525290; ClinicalTrialsRegister.EU identifier 2011-005906-32. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for patients with acute ischemic stroke with unknown time of onset and diffusion-weighted imaging-fluid-attenuated inversion recovery mismatch who received IV alteplase, CMBs are not significantly associated with functional outcome at 90 days.
Indexed as
Ischemic StrokeStrokeCerebral HemorrhageFibrinolytic AgentsHumansMaleProspective StudiesThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeFibrinolytic AgentsTissue Plasminogen Activator
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT01525290ClinicalTrials.gov
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