SynthesisJournal of neurology, neurosurgery, and psychiatry2022
Prevalence of dementia in ischaemic or mixed stroke populations: systematic review and meta-analysis.
Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Canadian Stroke Best Practice Recommendations: Vascular cognitive impairment, 7th edition practice guidelines update, 2024.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Guideline
- Plasma Human Cartilage Glycoprotein-39 and Cognitive Impairment After Acute Ischemic Stroke.Journal of the American Heart Association · 2025Trial
- Stroke-heart syndrome outcomes in pre-existing vs. new-onset dementia: a report from a global federated research network.Journal of thrombosis and thrombolysis · 2026Article
- Developing a core outcome set for intervention studies in post stroke cognitive impairment (COS-PSCI): a protocol.BMJ open · 2026Article
- The limited diagnostic and prognostic utility of brief cognitive screening tools in acute stroke.European stroke journal · 2026Article
- EGR2 affects mixed stroke repair through BNIP3L-mediated microglial mitophagy.IBRO neuroscience reports · 2026Article
- Vascular Cognitive Impairment and Dementia: Clinical Features, Neuropathology, and Biomarkers.Journal of the American College of Cardiology · 2026Review
- Impact of Statin Therapy on the Risk of Stroke Recurrence, Mortality, and Dementia After Ischemic Stroke (ISMARDD Study): A Comprehensive Meta-Analysis.Neurology international · 2025Article
- Statins in Acute Ischemic Stroke: Mechanisms, Resistance, and Precision Strategies for Neurovascular and Cognitive Protection.CNS drugs · 2025Review
- Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling.Brain and behavior · 2025Article
- Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study.The Lancet regional health. Europe · 2025Article
- Association between post-stroke cognitive impairment and gut microbiota in patients with ischemic stroke.Scientific reports · 2025Article
- Article
- Efficacy and safety of idebenone tablets in patients with post-stroke cognitive impairment: a real-world study.Frontiers in neurology · 2025Article
- Peripheral and central auditory dysfunction, cardiometabolic multimorbidity, and cognitive performance in community-dwelling older adults: a cross-sectional study.Frontiers in neuroscience · 2025Article
- Altered brain dynamics in post-stroke cognitive and motor dysfunction.Frontiers in aging neuroscience · 2025Article
- A modified Delphi survey to build expert consensus on the structure and content of an enhanced care pathway for cognitive changes after stroke in the UK.BMC health services research · 2024Article
- Vascular cognitive impairment and dementia: Mechanisms, treatment, and future directions.International journal of stroke : official journal of the International Stroke Society · 2024Review
- Age, sex, and APOE gene-specific associations between dynapenic obesity and dementia in a large cohort.The journal of nutrition, health & aging · 2024Article
- Spiritual needs and influencing factors among people with stroke in China: a cross-sectional study.BMC nursing · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
An understanding of the epidemiology of poststroke dementia (PSD) is necessary to inform research, practice and policy. With increasing primary studies, a contemporary review of PSD could allow for analyses of incidence and prevalence trends. Databases were searched using a prespecified search strategy. Eligible studies described an ischaemic or mixed stroke cohort with prospective clinical assessment for dementia. Pooled prevalence of dementia was calculated using random-effects models at any time after stroke (primary outcome) and at 1 year (range: 6-18 months), stratified for inclusion of prestroke dementia. Meta-regression explored the effect of year of study. Sensitivity analyses removed low-quality or outlier studies. Of 12 505 titles assessed, 44 studies were included in the quantitative analyses. At any time point after stroke, the prevalence of PSD was 16.5% (95% CI 10.4% to 25.1%) excluding prestroke dementia and 22.3% (95% CI 18.8% to 26.2%) including prestroke dementia. At 1 year, the prevalence of PSD was 18.4% (95% CI 7.4% to 38.7%) and 20.4% (95% CI 14.2% to 28.2%) with prestroke dementia included. In studies including prestroke dementia there was a negative association between dementia prevalence and year of study (slope coefficient=-0.05 (SD: 0.01), p<0.0001). Estimates were robust to sensitivity analyses. Dementia is common following stroke. At any point following stroke, more than one in five people will have dementia, although a proportion of this dementia predates the stroke. Declining prevalence of prestroke dementia may explain apparent reduction in PSD over time. Risk of dementia following stroke remains substantial and front-loaded, with high prevalence at 1 year post event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.