Evidence map›Paper›PMID 34782351›Full record

ArticleDiabetes2021

Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases.

William T Cefalu, Dana K Andersen, Guillermo Arreaza-Rubín, Christopher L Pin, Sheryl Sato, C Bruce Verchere, Minna Woo, Norman D Rosenblum, symposium planning committee, moderators, and speakers

Open access · hybridAbstract read
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Scaling Insulin-Producing Cells by Multiple Strategies.Endocrinology and metabolism (Seoul, Korea) · 2024
    Review
  5. Dysregulated UPR and ER Stress Related to a Mutation in theInternational journal of molecular sciences · 2023
    Article
  6. Precision Medicine in Type 1 Diabetes.Journal of the Indian Institute of Science · 2023
    Review
  7. Article
  8. Role of the Pancreatic Islet Microvasculature in Health and Disease.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

William T CefaluDivision of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD william.cefalu@nih.gov.
Dana K AndersenDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Guillermo Arreaza-RubínDivision of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Christopher L PinDepartments of Physiology and Pharmacology, Paediatrics, and Oncology, University of Western Ontario, and Genetics and Development Division, Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada.
Sheryl SatoDivision of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
C Bruce VerchereDepartments of Surgery and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Minna WooDepartments of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-5163-0112
Norman D Rosenblum
symposium planning committee, moderators, and speakers
National Institutes of Health · USCanadian Institutes of Health Research · CAUniversity Health Network · CAUniversity of British Columbia · CAWestern University · CA

Funding

Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic backgroundR01DK124395 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI REDONDO, MARIA JOSE · 2021 to 2024
$2.6M
Type 1 Diabetes Genetic Risk Score in TrialNetR01DK121843 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI REDONDO, MARIA JOSE · 2019 to 2023
$2.4M
Clinical Implications of Genetically Defined Diabetes Subtypes and Application to Electronic Health Medical Record SystemsK23DK114551 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UDLER, MIRIAM SARGON · 2017 to 2021
$1000k
Extension of Type 2 Diabetes Genetic Clustering to Populations of non-European AncestryR03DK131249 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UDLER, MIRIAM SARGON · 2022 to 2023
$252k
NIDDK NIH HHS K23 DK114551NIDDK NIH HHS R01 DK121843NIDDK NIH HHS R01 DK124395NIDDK NIH HHS R03 DK131249
6 · The paper itself

Abstract

One hundred years have passed since the discovery of insulin-an achievement that transformed diabetes from a fatal illness into a manageable chronic condition. The decades since that momentous achievement have brought ever more rapid innovation and advancement in diabetes research and clinical care. To celebrate the important work of the past century and help to chart a course for its continuation into the next, the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases recently held a joint international symposium, bringing together a cohort of researchers with diverse interests and backgrounds from both countries and beyond to discuss their collective quest to better understand the heterogeneity of diabetes and thus gain insights to inform new directions in diabetes treatment and prevention. This article summarizes the proceedings of that symposium, which spanned cutting-edge research into various aspects of islet biology, the heterogeneity of diabetic phenotypes, and the current state of and future prospects for precision medicine in diabetes.

Identifiers

PMID34782351
PMCPMC8763877
OpenAlexW3214319233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.