Evidence map›Paper›PMID 34782304›Full record

ArticleAdvances in biological regulation2022

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis.

Yann Desfougères, Paloma Portela-Torres, Danye Qiu, Thomas M Livermore, Robert K Harmel, Filipy Borghi, Henning J Jessen, Dorothea Fiedler, Adolfo Saiardi

Open access · hybridAbstract read
In one paragraph

Article in Advances in biological regulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Affinity-Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6-PP-InsPAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Enabling Technologies for the Dissection of Inositol Pyrophosphate Physiology.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Arg1 frommBio · 2024
    Article
  10. Review
  11. β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yann DesfougèresMedical Research Council, Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK.
Paloma Portela-TorresMedical Research Council, Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK.
Danye QiuInstitute of Organic Chemistry, CIBSS - The Center for Integrative Biological Signalling Studies, University of Freiburg, Albertstr. 21, 79104, Freiburg, Germany.
Thomas M LivermoreMedical Research Council, Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK.
Robert K HarmelLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Straße 10, 13125, Berlin, Germany.
Filipy BorghiMedical Research Council, Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK.
Henning J JessenInstitute of Organic Chemistry, CIBSS - The Center for Integrative Biological Signalling Studies, University of Freiburg, Albertstr. 21, 79104, Freiburg, Germany.
Dorothea FiedlerLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Straße 10, 13125, Berlin, Germany.
Adolfo SaiardiMedical Research Council, Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK. Electronic address: a.saiardi@ucl.ac.uk.
MRC Laboratory for Molecular Cell Biology · GBLeibniz-Forschungsinstitut für Molekulare Pharmakologie · DEUniversity of Freiburg · DE

Funding

Medical Research Council MR/T028904/1
6 · The paper itself

Abstract

Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP

Indexed as

DictyosteliumAnimalsDiphosphatesHumansInositol PhosphatesMammalsPhosphotransferases (Phosphate Group Acceptor)PolyphosphatesDiphosphatesdiphosphoric acidInositol PhosphatesPhosphotransferases (Phosphate Group Acceptor)PolyphosphatesAmoebaDevelopmentInorganic polyphosphatesInositolip6kMetabolismPhosphateppip5k

Identifiers

PMID34782304
PMCPMC8885430
OpenAlexW3213186987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.