Evidence map›Paper›PMID 34781988›Full record

ArticleTrials2021

Gas embolism under standard versus low pneumoperitoneum pressure during laparoscopic liver resection (GASES): study protocol for a randomized controlled trial.

Danfeng Jin, Mingyue Liu, Jian Huang, Yongfeng Xu, Luping Liu, Changhong Miao, Jing Zhong

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Danfeng Jin *Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Mingyue Liu *Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Jian Huang *Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Yongfeng XuDepartment of Hepatology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Luping LiuDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Changhong MiaoDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Jing ZhongDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China. jzhong12@fudan.edu.cn.
Zhongshan Hospital · CNFudan University · CNSun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

Excellent Backbone Plan Of Zhongshan Hospital 2021ZSGG16National Natural Science Foundation of China 81971868National Natural Science Foundation of China 82072213Program of Shanghai Academic Research Leader 20XD1423000Special Fund For Clinical Research Of Zhongshan Hospital No. 2020ZSLC41
6 · The paper itself

Abstract

backgroundGas embolism induced by CO

methodsAdult participants (n = 140) undergoing elective LLR will be allocated to either a standard (15 mmHg) or low (10 mmHg) PP group. Anesthesia management, postoperative care, and other processes will be performed similarly in both groups. The occurrence of severe gas embolism, which is defined as gas embolism ≥ grade 3 according to the Schmandra microbubble method, will be detected by transesophageal echocardiography (TEE) and recorded as the primary outcome. The subjects will be followed up until discharge and followed up by telephone 1 and 3 months after surgery. Postoperative outcomes, such as the Post-Operative Quality of Recovery Scale, pain severity, and adverse events, will be assessed. Serum cardiac markers and inflammatory factors will also be assessed during the study period. The correlation between intraoperative inferior vena cava-collapsibility index (IVC-CI) under TEE and central venous pressure (CVP) will also be explored. DISCUSSION: This study is the first prospective randomized clinical trial to determine the effect of low versus standard PP on gas embolism using TEE during elective LLR. These findings will provide scientific and clinical evidence of the role of PP. TRIAL STATUS: Protocol version: version 1 of 21-08-2020

trial registrationChiCTR2000036396 ( http://www.chictr.org.cn ). Registered on 22 August 2020.

Indexed as

Embolism, AirLaparoscopyPneumoperitoneumAdultCarbon DioxideGasesHumansLiverPneumoperitoneum, ArtificialProspective StudiesRandomized Controlled Trials as TopicCarbon DioxideGasesGas embolismInferior vena cava-collapsibility index (IVC-CI)Laparoscopic liver resection (LLR)Pneumoperitoneum pressure (PP)Randomized controlled trial

Identifiers

PMID34781988
PMCPMC8591437
OpenAlexW3212204869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.