Evidence map›Paper›PMID 34781968›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2021

Adverse fibrosis remodeling and aortopulmonary collateral flow are associated with poor Fontan outcomes.

Andrea Pisesky, Marjolein J E Reichert, Charlotte de Lange, Mike Seed, Shi-Joon Yoo, Christopher Z Lam, Lars Grosse-Wortmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Andrea PiseskyDepartment of Paediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Labatt Family Heart Center, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. andrea.pisesky@sickkids.ca.ORCID 0000-0003-0094-0193
Marjolein J E ReichertDepartment of Paediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Labatt Family Heart Center, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Charlotte de LangeDivision of Radiology and Nuclear Medicine, Pediatric section, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Mike SeedDepartment of Paediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Labatt Family Heart Center, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Shi-Joon YooDepartment of Paediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Labatt Family Heart Center, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Christopher Z LamDepartment of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Lars Grosse-WortmannDepartment of Paediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Labatt Family Heart Center, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
University of Toronto · CAOregon Health & Science University · USOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe extent and significance in of cardiac remodeling in Fontan patients are unclear and were the subject of this study.

methodsThis retrospective cohort study compared cardiovascular magnetic resonance (CMR) imaging markers of cardiac function, myocardial fibrosis, and hemodynamics in young Fontan patients to controls.

resultsFifty-five Fontan patients and 44 healthy controls were included (median age 14 years (range 7-17 years) vs 13 years (range 4-14 years), p = 0.057). Fontan patients had a higher indexed end-diastolic ventricular volume (EDVI 129 ml/m

conclusionsPediatric Fontan patients have ventricular dysfunction, altered myocardial mechanics and increased fibrotic remodeling. Cumulative exposure to cardiopulmonary bypass and increased aortopulmonary collateral flow are associated with myocardial dysfunction and fibrosis. Cardiac dysfunction, fibrosis, and collateral flow are associated with adverse outcomes.

Indexed as

Heart VentriclesMagnetic Resonance Imaging, CineAdolescentChildFibrosisHumansPredictive Value of TestsRetrospective StudiesVentricular Function, LeftCongenital heart diseaseFibrosisFontanHeart failureMagnetic resonance imaging

Identifiers

PMID34781968
PMCPMC8591885
OpenAlexW3213077085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.