Evidence map›Paper›PMID 34781939›Full record

ArticleCardiovascular diabetology2021

Association of glycated hemoglobin A

Christoph Sinning, Nataliya Makarova, Henry Völzke, Renate B Schnabel, Francisco Ojeda, Marcus Dörr, Stephan B Felix, Wolfgang Koenig, Annette Peters, Wolfgang Rathmann and 14 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 5 countries.

Christoph Sinning *Department of Cardiology, University Heart & Vascular Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany. c.sinning@uke.de.ORCID http://orcid.org/0000-0002-7331-8840
Nataliya Makarova *Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Henry VölzkeDepartment of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Renate B SchnabelDepartment of Cardiology, University Heart & Vascular Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany.
Francisco OjedaDepartment of Cardiology, University Heart & Vascular Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany.
Marcus DörrGerman Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
Stephan B FelixGerman Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
Wolfgang KoenigGerman Heart Center Munich, Technical University, Munich, Germany.
Annette PetersGerman Research Center for Environmental Health, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Wolfgang RathmannInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany.
Giovanni VeronesiDepartment of Medicine and Surgery, EPIMED Research Center, University of Insubria at Varese, Varese, Italy.
Giancarlo CesanaDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Paolo BrambillaDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Tarja PalosaariFinnish Institute for Health and Welfare, Division Public Health and Welfare, Helsinki, Finland.
Kari KuulasmaaFinnish Institute for Health and Welfare, Division Public Health and Welfare, Helsinki, Finland.
Inger NjølstadDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsö, Norway.
Ellisiv Bøgeberg MathiesenBrain and Circulation Research Group, UiT The Arctic University of Norway, Tromsö, Norway.
Tom WilsgaardDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsö, Norway.
Stefan BlankenbergDepartment of Cardiology, University Heart & Vascular Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany.
Stefan Söderberg *Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Marco M Ferrario *Department of Medicine and Surgery, EPIMED Research Center, University of Insubria at Varese, Varese, Italy.
Barbara Thorand *German Research Center for Environmental Health, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8416-6440
Universitätsmedizin Greifswald · DEFinnish Institute for Health and Welfare · FIGerman Cancer Research Center · DEGerman Centre for Cardiovascular Research · DEHelmholtz Zentrum München · DEUiT The Arctic University of Norway · NOUniversität Hamburg · DEUniversity of Insubria · ITUniversity of Milano-Bicocca · ITDeutsches Diabetes-Zentrum e.V. · DEUmeå University · SEUniversität Ulm · DEUniversity Hospital of North Norway · NO

Funding

Medical Research Council G0601463
6 · The paper itself

Abstract

backgroundBiomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A

methodsData from six prospective population-based cohort studies across Europe comprising 36,180 participants were analyzed. HbA

resultsKaplan-Meier curves showed higher event rates with increasing HbA

conclusionsHbA

Indexed as

AgedBiomarkersCardiovascular DiseasesDiabetes MellitusEuropeFemaleGlycated HemoglobinHeart Disease Risk FactorsHumansIncidenceMaleMiddle AgedPrognosisRisk AssessmentTime FactorsBiomarkersGlycated Hemoglobinhemoglobin A1c protein, humanBiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe)BiomarkersCardiovascular riskGlycated hemoglobin A1c (HbA1c)MORGAM (MONICA Risk Genetics Archiving and Monograph)Mortality

Identifiers

PMID34781939
PMCPMC8594211
OpenAlexW3190594490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.