ArticleBMC psychiatry2021
Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study.
Article in BMC psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Inter-network Effective Connectivity During an Emotional Working Memory Task in Two Independent Samples of Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Correlations between depressive symptoms, verbal working memory, and physical activity in university students: evidence based on resting EEG.BMC psychiatry · 2025Article
- The paradoxical impact of periodic limb movements on isolated REM sleep behavior disorder patients.Journal of neurology · 2024Article
- Avoidance-motivational intensity modulated the effect of negative emotion on working memory.Royal Society open science · 2023Article
- Central Adiponectin Signaling - A Metabolic Regulator in Support of Brain Plasticity.Brain plasticity (Amsterdam, Netherlands) · 2022Review
- Comparing the Working Memory Capacity with Cognitive Flexibility, Cognitive Emotion Regulation, and Learning Styles of University Students: A Domain General View.Dementia and geriatric cognitive disorders extraArticle
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Authors and funding
10 authors.
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Abstract
backgroundDepressive symptoms could be similarly expressed in bipolar and unipolar disorder. However, changes in cognition and brain networks might be quite distinct. We aimed to find out the difference in the neural mechanism of impaired working memory in patients with bipolar and unipolar disorder.
methodAccording to diagnostic criteria of bipolar II disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and assessments, 13 bipolar II depression (BP II), 8 unipolar depression (UD) patients and 15 healthy controls (HC) were recruited in the study. We used 2-back tasks and magnetic source imaging (MSI) to test working memory functions and get the brain reactions of the participants.
resultsCompared with HC, only spatial working memory tasks accuracy was significantly worse in both UD and BP II (p = 0.001). Pearson correlation showed that the stronger the FCs' strength of MFG-IPL and IPL-preSMA, the higher accuracy of SWM task within left FPN in patients with UD (r = 0.860, p = 0.006; r = 0.752, p = 0.031). However, the FC strength of IFG-IPL was negatively correlated with the accuracy of SWM task within left FPN in patients with BP II (r = - 0.591, p = 0.033).
conclusionsOur study showed that the spatial working memory of patients with whether UD or BP II was impaired. The patterns of FCs within these two groups of patients were different when performing working memory tasks.
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