ArticleBMC infectious diseases2021
Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 15 citations in OpenAlex.
- HPV E6/E7 mRNA vs. HPV DNA in co-testing with ThinPrep cytology for cervical cancer screening: a prospective observational diagnostic accuracy study of methylation biomarkers.Journal of gynecologic oncology · 2026Observational
- The Epidemiology of Human Papillomavirus (HPV) Infections in Poland in the Light of the Nationwide HPV Vaccination Program for Children Aged 12-13 and Updated HPV DNA Detection Guidelines.International journal of molecular sciences · 2026Article
- Article
- Risk factors for HR-HPV persistence and residual or recurrent high-grade squamous intraepithelial neoplasia after LEEP.Frontiers in medicine · 2026Article
- Prevalence and Genotype Distribution of Human Papillomavirus in 23,495 Cases in Guangzhou City, Guangdong Province, China.Current microbiology · 2025Article
- Patterns of Co-infection of HPV52 With Other HPV Genotypes and Their Risks of Cervical Precancer and Carcinoma.Journal of medical virology · 2025Article
- Study on the clinical characteristics, persistent infection capability, and viral load of human papillomavirus type 82 single infection.Virology journal · 2025Article
- Genotypic analysis of human papillomavirus in cervical exfoliated cells from women in Zigong.Virology journal · 2025Article
- A 10-year Retrospective Analysis on HPV Genotype Switching in a Tertiary Center in China: Infection Characterization and Clinical Outcome.Journal of medical virology · 2025Article
- Study on the clinical characteristics, persistent infection capability and viral load of human papillomavirus type 26 single infection.Virology journal · 2024Article
- Endometriosis specific vaginal microbiota links to urine and serum N-glycome.Scientific reports · 2024Article
- Accuracy of GynTectCancers · 2024Article
- Prevalence and genotype distribution of human papillomavirus infection among 66000 women from 2014 to 2023 in the plateau region of Southwest China.Virology journal · 2024Article
- Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications.Cancers · 2023Review
- Prevalence of human papillomavirus genotypes and related cervical morphological results in southern Hunan Province of China, 2018-2020: Baseline measures at a tertiary institution prior to mass human papillomavirus vaccination.Frontiers in microbiology · 2022Article
- The Infection Status and Distribution of hrHPV in Cervical Lesions Among Overweight Women Referred for Colposcopy: A Cross-Sectional Study.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics of HPV infections, including the HPV genotype and duration of infection, determine a patient's risk of high-grade lesions. Risk quantification of cervical lesions caused by different HPV genotypes is an important component of evaluation of cervical lesion. Data and evidence are necessary to gain a deeper understanding of the pathogenicity of different HPV genotypes. The present study investigated the clinical characteristics of patients infected with single human papillomavirus (HPV) 53.
methodsThis retrospective study analyzed the clinical data of patients who underwent cervical colposcopy guided biopsy between October 2015 and January 2021. The clinical outcomes and the follow-up results of the patients with single HPV53 infection were described.
results82.3% of the initial histological results of all 419 patients with single HPV53 infection showed negative (Neg). The number of patients with cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, vaginal intraepithelial neoplasia (VaIN)1, CIN1 + VaIN1, CIN1 + VaIN2, and CIN2 + VaIN2 was 45, 10, 2, 9, 6, 1, and 1, respectively. Cancer was not detected in any patient. When the cytology was negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL), we observed a significant difference in the distribution of histological results (P < 0.05). 95 patients underwent follow-up with cytology according to the exclusion criteria. No progression of high-grade lesions was observed during the follow-up period of 3-34 months.
conclusionsThe lesion caused by HPV53 infection progressed slowly. The pathogenicity of a single HPV53 infection was low.
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