Evidence map›Paper›PMID 34781821›Full record

ArticleGut microbes

Caitlin A Brennan, Slater L Clay, Sydney L Lavoie, Sena Bae, Jessica K Lang, Diogo Fonseca-Pereira, Kathryn G Rosinski, Nora Ou, Jonathan N Glickman, Wendy S Garrett

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Global research trends inFrontiers in cellular and infection microbiology · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. mTOR-Gut Microbiome Interaction in Aging: Fusobacterium nucleatum, Resistance Training and Multi-nutrient Supplementation Effects in Aged Male Rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  11. Observational
  12. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Contextualizing TNature reviews. Immunology · 2026
    Review
  18. Pathogenic Roles ofPathogens (Basel, Switzerland) · 2026
    Review
  19. Article
  20. Review

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Caitlin A BrennanDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Slater L ClayDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Sydney L LavoieDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Sena BaeDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Jessica K LangDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Diogo Fonseca-PereiraDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Kathryn G RosinskiDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Nora OuDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Jonathan N GlickmanDepartment of Pathology, Harvard Medical School, Boston, Massachusetts.
Wendy S GarrettDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Harvard University · USDana-Farber Cancer Institute · USHadassah Medical Center · IL

Funding

Gut microbiota and inflammatory monocytes in colorectal cancerR01CA154426 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI GARRETT, WENDY S. · 2011 to 2025
$5.2M
Cancer Immunology Training GrantT32CA207021 · NCI · DANA-FARBER CANCER INST · PI WUCHERPFENNIG, KAI W · 2016 to 2020
$2.4M
Cancer Research UK 27140NCI NIH HHS R01 CA154426NCI NIH HHS T32 CA207021
6 · The paper itself

Abstract

The colorectal cancer (CRC)-associated microbiota creates a pro-tumorigenic intestinal milieu and shapes immune responses within the tumor microenvironment. However, how oncomicrobes - like

Indexed as

AnimalsColonColorectal NeoplasmsFemaleFusobacterium nucleatumGastrointestinal MicrobiomeHumansInterleukin-17Intestinal MucosaMaleMiceMice, Inbred C57BLReceptors, G-Protein-CoupledTh17 CellsFfar2 protein, mouseIl17a protein, mouseInterleukin-17Receptors, G-Protein-Coupledaltered Schaedler’s floracolorectal cancerFusobacterium nucleatumgnotobioticsinterleukin 17MicrobiomeTh17 cells

Identifiers

PMID34781821
PMCPMC8604392
OpenAlexW3212249097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.