Evidence map›Paper›PMID 34781744›Full record

ArticlemBio2021

The Intersection of the Staphylococcus aureus Rex and SrrAB Regulons: an Example of Metabolic Evolution That Maximizes Resistance to Immune Radicals.

Aidan Dmitriev, Xingru Chen, Elyse Paluscio, Amelia C Stephens, Srijon K Banerjee, Nicholas P Vitko, Anthony R Richardson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Journal of bacteriology · 2025
    Article
  5. Article
  6. Review
  7. Response ofJournal of bacteriology · 2024
    Article
  8. Quorum-sensingeLife · 2024
    Article
  9. Quorum-sensingbioRxiv : the preprint server for biology · 2024
    Article
  10. Factors impacting the regulation ofMicrobiology spectrum · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aidan DmitrievDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Xingru ChenDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Elyse PaluscioDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Amelia C StephensDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6356-4546
Srijon K BanerjeeDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Nicholas P VitkoDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Anthony R RichardsonDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1123-0242
University of Pittsburgh · USUniversity of North Carolina at Chapel Hill · US

Funding

Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
The Role of Lactate in the Metabolic Evolution of Staphylococcus aureusR01AI093613 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RICHARDSON, ANTHONY R. · 2011 to 2021
$3.6M
NIAID NIH HHS R01 AI093613NIAID NIH HHS T32 AI060525
6 · The paper itself

Abstract

Staphylococcus aureus is the most pathogenic member of the

Indexed as

Evolution, MolecularRegulonAnaerobiosisBacterial ProteinsGene Expression Regulation, BacterialHumansNitric OxideRepressor ProteinsStaphylococcal InfectionsStaphylococcus aureusBacterial ProteinsNitric OxideRepressor ProteinsSrrB protein, Staphyolococcus aureuscoagulase-negative staphylococcifermentationimmune radicalsmetabolic evolutionmetabolismnitric oxideredox signalingStaphylococcus aureus

Identifiers

PMID34781744
PMCPMC8593685
OpenAlexW3211614791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.