ArticleKidney research and clinical practice2021
When and why to start continuous renal replacement therapy in critically ill patients with acute kidney injury.
Article in Kidney research and clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Volume control strategy and patient survival in sepsis-associated acute kidney injury receiving continuous renal replacement therapy: a randomized controlled trial with secondary analysis.Scientific reports · 2024Trial
- Early prediction of renal replacement therapy within 24 hours after septic shock recognition in the emergency department using machine learning: a retrospective analysis of a prospectively collected multicenter registry.BMC emergency medicine · 2026Article
- Korean Society of Nephrology 2025 Evidence-Based Clinical Practice Guideline for Continuous Kidney Replacement Therapy.Electrolyte & blood pressure : E & BP · 2026Review
- Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy.Kidney research and clinical practice · 2026Article
- Article
- The Prevalence of Cardiac Arrhythmias in COVID-19 Patients Undergoing CRRT During the First 24 Hours of ICU Admission.Medical journal of the Islamic Republic of Iran · 2026Article
- Exploring the Readiness of Critical Care in Implementing Continuous Renal Replacement Therapy in Hail Hospitals, Saudi Arabia: Findings for Acute Kidney Injury Patient Care Improvement.Healthcare (Basel, Switzerland) · 2025Article
- Early Urine Output in the Emergency Room as a Prognostic Indicator for Critically Ill Patients Undergoing Continuous Renal Replacement.Life (Basel, Switzerland) · 2025Article
- Global transplantation: Lessons from organ transplantation organizations worldwide.World journal of transplantation · 2025Review
- Dialysis decision in critically ill patients in intensive care unit.Acute and critical care · 2025Article
- Multifunctional Applications of Extracellular Nanovesicles for Acute Kidney Injury and Renal Fibrosis; a Mini Review.International journal of nanomedicine · 2025Review
- Article
- A Retrospective Study on the Start and End of Continuous Hemodialysis Using a Polymethylmethacrylate Hemofilter for Severe Acute Pancreatitis.Internal medicine (Tokyo, Japan) · 2024Article
- Data-driven prediction of continuous renal replacement therapy survival.Nature communications · 2024Article
- Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation.Frontiers in medicine · 2024Article
- Exosome-Based Drug Delivery: Translation from Bench to Clinic.Pharmaceutics · 2023Review
- Management for Electrolytes Disturbances during Continuous Renal Replacement Therapy.Electrolyte & blood pressure : E & BP · 2022Review
- The association between albumin corrected anion gap and ICU mortality in acute kidney injury patients requiring continuous renal replacement therapy.Internal and emergency medicine · 2022Article
- Nomogram for Risk Prediction of Mortality for Patients with Critical Cardiovascular Disease Treated by Continuous Renal Replacement Therapy in Coronary Care Unit.Reviews in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a common condition in critically ill patients, and may contribute to significant medical, social, and economic consequences, including death. Although there have been advances in medical technology, including continuous renal replacement therapy (CRRT), the mortality rate of AKI is high, and there is no fundamental treatment that can reverse disease progression. The decision to implement CRRT is often subjective and based primarily on the clinician's judgment without consistent and concrete guidelines or protocols regarding when to initiate and discontinue CRRT and how to manage complications. Recently, several randomized controlled trials addressing the initiation of renal replacement therapy in critically ill patients with AKI have been completed, but clinical application of the findings is limited by the heterogeneity of the objectives and research designs. In this review, the advantages and disadvantages of CRRT initiation, clinical guideline recommendations, and the results of currently published clinical trials and meta-analyses are summarized to guide patient care and identify future research priorities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.