Evidence map›Paper›PMID 34781185›Full record

ArticleTranslational oncology2022

Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy.

Hui Du, Ozioma Udochukwu Akakuru, Chenyang Yao, Fang Yang, Aiguo Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui DuCAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Ningbo 315201, PR China; University of Chinese Academy of Sciences, Beijing 100049, China.
Ozioma Udochukwu AkakuruCAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Ningbo 315201, PR China.
Chenyang YaoCAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Ningbo 315201, PR China; University of Chinese Academy of Sciences, Beijing 100049, China.
Fang YangCAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Ningbo 315201, PR China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, PR China. Electronic address: yangf@nimte.ac.cn.
Aiguo WuCAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Ningbo 315201, PR China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, PR China. Electronic address: aiguo@nimte.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic nanoparticles (MNPs) have been extensively researched and implemented in biomedicine for more than half a century due to their non-invasive nature, ease of temporal and spatial manipulation, and considerable biocompatibility. However, the complex magnetic behaviour of MNPs is influenced by several parameters (e.g., particle size, shape, composition, core-shell structure, etc.), among which the amount of transition metal doping plays an important factor. For this reason, the doping of ferrite with transition metals has been used as an effective strategy to precisely tailor MNPs to achieve satisfactory performance in biomedical applications. In this review, we first introduced the main properties of coordinated MNPs (including magnetic moment and saturated magnetisation) and provide a comprehensive overview of the mechanistic studies related to the doping of transition metal ions into ferrite to precisely modulate its magnetic properties. We also highlighted the potential mechanisms and recent advances in transition metal ion-doped MNPs (TMNPs) for bioimaging (magnetic resonance imaging and magnetic particle imaging) and tumour therapy (e.g., magneto-mechanical killing, magnetothermal therapy, and drug delivery). Finally, we summarised the current challenges and future trends of TMNPs in the biomedical field based on the latest advances by researchers.

Indexed as

BioimagingCancer therapyDopantMagnetic nanomaterialsTransition metals

Identifiers

PMID34781185
PMCPMC8593663

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.