Evidence map›Paper›PMID 34780920›Full record

ArticleNeuroscience2022

Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model.

Rachel Humphries, Jack R Mellor, Cian O'Donnell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Rachel HumphriesCenter for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol BS8 1TD, UK; Computational Neuroscience Unit, School of Computer Science, Electrical and Electronic Engineering, and Engineering Mathematics, University of Bristol, Bristol BS8 1UB, UK.
Jack R MellorCenter for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Cian O'DonnellComputational Neuroscience Unit, School of Computer Science, Electrical and Electronic Engineering, and Engineering Mathematics, University of Bristol, Bristol BS8 1UB, UK; School of Computing, Engineering and Intelligent Systems, Ulster University, Magee Campus, Northland Road, Derry/Londonderry BT48 7JL, UK. Electronic address: cian.odonnell@bristol.ac.uk.
University of Bristol · GBUniversity of Ulster · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R002177/1Medical Research Council MR/S026630/1Wellcome Trust 101029Wellcome Trust 101029/Z/13/Z
6 · The paper itself

Abstract

Acetylcholine has been proposed to facilitate the formation of memory ensembles within the hippocampal CA3 network, by enhancing plasticity at CA3-CA3 recurrent synapses. Regenerative NMDA receptor (NMDAR) activation in CA3 neuron dendrites (NMDA spikes) increase synaptic Ca

Indexed as

AcetylcholineN-MethylaspartateDendritesHippocampusPotassium ChannelsPyramidal CellsSynapsesAcetylcholineN-MethylaspartatePotassium ChannelsCA3computational modellingdendritic spikeshippocampusNMDA receptorssynaptic plasticity

Identifiers

PMID34780920
PMCPMC7614718
OpenAlexW3212997935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.